Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human, Bovine, Dog, Rabbit (tested or 100% immunogen sequence identity)
Monkey, Mouse, Rat, Bat, Guinea pig, Pig (at least 90% immunogen sequence identity)
IHC - Paraffin (3.75 - 7.5 µg/ml)
Specificity and Use
KCNN4 / KCa3.1 antibody was raised against synthetic peptide C-ERQAVNATGHLSD from positions 227-239 of human KCNN4 (NP_002241.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Marmoset, Elephant, Panda, Bovine, Dog, Rabbit (100%); Monkey, Mouse, Rat, Bat, Pig, Guinea pig (92%).
Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin.