Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse, Rat (tested or 100% immunogen sequence identity)
Western blot (1:200 - 1:500)
Specificity and Use
KCNMA1 / BK antibody was raised against gST fusion protein corresponding to residues 1098-1196 of mouse Slo (mSlo) (Accession A48206).
Recognizes BKCa Channel. Splice forms sequence homology: Corresponds to the C-terminus of the longer form of BKCa channel alpha subunit. Overlaps by >40 residues with a shorter form. Species cross-reactivity: Rat and mouse. Species sequence homology: Chicken: 91/99; rabbit: 88/99; turtle: 87/99.
Suitable for use in Western Blot and Immunohistochemistry. Western Blot: 1:200-1:500 (rat brain membranes). Preadsorption Control: 3 ug fusion protein (B2103A) per 1 ug antibody. Immunohistochemistry: Rat uterus and brain sections.
Potassium channel activated by both membrane depolarization or increase in cytosolic Ca2+ that mediates export of K+. It is also activated by the concentration of cytosolic Mg2+. Its activation dampens the excitatory events that elevate the cytosolic Ca2+ concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential.