Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
(applications tested for the base form of this product only)
Specificity and Use
KCNK2 / TREK-1 antibody was raised against a synthetic peptide within the N-terminal region [residues 1-100] of the human TREK 1 protein. [Swiss-Prot# Q9NRT2]. Percent identity by BLAST analysis: Rat (88%).
Tris-glycine, 150 mM sodium chloride, 0.05% sodium azide.
TREK1 is a 2 pore-domain 4 transmembrane domain background potassium channel expressed throughout the central nervous system with lower levels in peripheral tissues. It is opened by polyunsaturated fatty acids, lysophospholipids, and volatile anesthetics. It is inhibited by neurotransmitters that increase intracellular cAMP or activate the Gq signaling pathway.