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KAT2A / GCN5
K(lysine) acetyltransferase 2A
Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
| Gene Name: | K(lysine) acetyltransferase 2A |
| Synonyms: | KAT2A, GCN5, HsGCN5, K(lysine) acetyltransferase 2A, GCN5L2, Lysine acetyltransferase 2A, Histone acetyltransferase GCN5, HGCN5, PCAF-b, STAF97 |
| Target Sequences: | NM_021078 NP_066564.2 Q92830 |
Publications (3)
1
The double-histone-acetyltransferase complex ATAC is essential for mammalian development. Guelman S, Kozuka K, Mao Y, Pham V, Solloway MJ, Wang J, Wu J, Lill JR, Zha J. Molecular and cellular biology. 2009 29:1176-88.
[PubMed:19103755]
[PMC:PMC2643826]
2
Sirtuin 1 (SIRT1) deacetylase activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) deacetylation following endurance exercise. Philp A, Chen A, Lan D, Meyer GA, Murphy AN, Knapp AE, Olfert IM, McCurdy CE, Marcotte GR, Hogan MC, Baar K, Schenk S. The Journal of biological chemistry. 2011 286:30561-70.
[PubMed:21757760]
[PMC:PMC3162416]
3
Reelin is a target of polyglutamine expanded ataxin-7 in human spinocerebellar ataxia type 7 (SCA7) astrocytes. McCullough SD, Xu X, Dent SY, Bekiranov S, Roeder RG, Grant PA. Proceedings of the National Academy of Sciences of the United States of America. 2012 109:21319-24.
[PubMed:23236151]
[PMC:PMC3535616]
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(24)
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(6)
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(24)
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KAT2A / GCN5
(30)
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(24)
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(10)
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(4)
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(1)
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(7)
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(24)
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(1)
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(20)
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(1)
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(14)
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(1)
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(1)
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(3)
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(21)
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(1)
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(1)
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(19)
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aa611-638
(7)
660-740 aa, C-terminal
(1)
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(1)
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(1)
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(1)
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(1)
aa691-740
(1)
aa75-106
(1)
aa807-837
(1)
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No
(30)
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(2)
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(2)
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(2)
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Human
(5)
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293T Cells
(1)
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(1)
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(1)
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(1)
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(2)
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Purified
(1)
![KAT2A / GCN5 Antibody - Immunoperoxidase of monoclonal antibody to GCN5L2 on formalin-fixed paraffin-embedded human colon. [antibody concentration 3 ug/ml]](https://lsbio-7d62.kxcdn.com/image2/kat2a-gcn5-antibody-clone-3f8-ls-c133217/50807_4892682.jpg)
KAT2A / GCN5 Mouse anti-Human Monoclonal (3F8) Antibody
Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µg/$423
KAT2A / GCN5 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Chicken, Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$299
KAT2A / GCN5 Rabbit anti-Human Polyclonal (aa691-740) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100 µl/$515
KAT2A / GCN5 Rabbit anti-Human Polyclonal (aa75-106) Antibody
Mouse, Rat, Human
WB
Unconjugated
10 µg/$318; 100 µg/$470
KAT2A / GCN5 Rabbit anti-Human Polyclonal (660-740 aa, C-terminal) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
KAT2A / GCN5 Mouse anti-Human Monoclonal (aa411-837) Antibody
Human
IF, WB
Unconjugated
50 µl/$303; 100 µl/$365
KAT2A / GCN5 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
KAT2A / GCN5 Rabbit anti-Human Polyclonal (Gly720) Antibody
Mouse, Human
IHC, WB
Unconjugated
50 µl/$321; 100 µl/$403
KAT2A / GCN5 Rabbit anti-Human Polyclonal (aa807-837) Antibody
Mouse, Human
Flo, WB
Unconjugated
400 µl/$393
KAT2A / GCN5 Rabbit-New Zealand White anti-Human Polyclonal Antibody
Human
IHC, WB
Unconjugated
100 µl/$393
KAT2A / GCN5 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$341
KAT2A / GCN5 Rabbit anti-Human Polyclonal (aa611-638) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
KAT2A / GCN5 Rabbit anti-Human Polyclonal (aa611-638) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
KAT2A / GCN5 Rabbit anti-Human Polyclonal (aa611-638) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
KAT2A / GCN5 Rabbit anti-Human Polyclonal (aa611-638) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
KAT2A / GCN5 Rabbit anti-Human Polyclonal (aa611-638) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
KAT2A / GCN5 Rabbit anti-Human Polyclonal (aa611-638) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
KAT2A / GCN5 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µg/$357
KAT2A / GCN5 Rabbit anti-Human Polyclonal (aa671-720) Antibody
Mouse, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
KAT2A / GCN5 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
KAT2A / GCN5 Mouse anti-Human Monoclonal Antibody
Human
WB
Unconjugated
100 µg/$786
KAT2A / GCN5 Rabbit anti-Human Polyclonal (aa65-94) Antibody
Human
WB
Unconjugated
400 µl/$393
KAT2A / GCN5 Rabbit anti-Human Polyclonal (aa611-638) Antibody
Human
WB
Unconjugated
400 µl/$393
KAT2A / GCN5 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µg/$575
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
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product results
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