Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Junction Plakoglobin antibody LS-B12183 is an unconjugated rabbit polyclonal antibody to Junction Plakoglobin (JUP / CTNNG) from human, mouse, dog and other species. Validated for IF, IHC, IP and WB. Tested on 20 paraffin-embedded human tissues.
Human, Mouse, Dog, Rabbit
(tested or 100% immunogen sequence identity)
IHC - Paraffin (5 µg/ml)
Immunofluorescence (1:250 - 1:1000)
Western blot (1:2000 - 1:10000)
Immunoprecipitation (2 - 10 µg/mg lysate)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Region between residue 695 and 745 of human Junction Plakoglobin using the numbering given in entry NP_002221.1 (GeneID 3728).
Immunohistochemistry: Antigen retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections. Human controls: Breast Carcinoma, Colon Carcinoma, Ovarian Carcinoma, Prostate Carcinoma.
Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques.