Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse, Human (tested or 100% immunogen sequence identity)
IHC - Frozen
Flow Cytometry (1:10)
Specificity and Use
Recognizes mouse JAM-C. Also reacts with human JAM-C.
Can be used for Immunoprecipitation, immunoassays as detector antibody, Immunohistology on frozen sections, Flow Cytometry and ELISA. Also useful for inhibition of biological activity. Immunohistology: 1:10. Flow Cytometry: 1:10. ELISA: 1:10. For inhibition of biological activity dilutions have to be made according to the amounts of JAM-C to be inhibited.
PBS, 0.1% BSA.
Short term: 4°C; Long term: Add glycerol (40-50%) -20°C.
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells.