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Anti-JAG1 / Jagged 1 Antibody (clone HMJ1-29) LS-C188668


Wt. Vol. Conc. Price
100 µg - 1 mg/ml $235
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)

Most Popular JAG1 / Jagged 1 Antibodies

Anti-JAG1 / Jagged 1 Antibody (aa110-125) LS-C71129
Rabbit Polyclonal (IgG) to Human JAG1 / Jagged 1
Human, Mouse, Rat
IHC - Paraffin, ICC, Immunofluorescence, Western blot, ELISA
Anti-JAG1 / Jagged 1 Antibody (aa32-296) LS-C149984
Goat Polyclonal (IgG) to Human JAG1 / Jagged 1
IHC - Paraffin, Western blot, ELISA
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Hamster Monoclonal [clone HMJ1-29] (IgG) to Mouse JAG1 / Jagged 1
Mouse, Rat
IHC - Frozen, Flow Cytometry


Mouse JAG1 / Jagged 1
Mouse, Rat (tested or 100% immunogen sequence identity)
IgG Monoclonal [HMJ1-29]
Protein G purified


  • IHC - Frozen
  • Flow Cytometry

Specificity and Use

JAG1 / Jagged 1 antibody was raised against jagged1-expressing CHO cells.
Recognizes CD339, otherwise known as Jagged1, one of the five major ligands of the Notch signalling pathway, which is activated through the binding of specific ligands to the Notch receptors Notch 1-4. The Notch signalling pathway is an evolutionarily conserved pathway in multi-cellular organisms, which is vital for cell-cell communication, important during fundamental developmental and physiological processes, including regulation of cell fate decisions during neuronal, cardiac and endocrine development, stem cell haematopoiesis, thymic T-cell development, and both tumor progression and suppression. Ligation of Notch receptors by their specific ligands, Jagged1 (CD339), Jagged2, Delta like-1 (DLL1), DLL3 and DLL4, on physically adjacent signal receiving cells, induces proteolysis of the receptors by ADAM-family metalloproteases and gamma-secretase complex, within the transmembrane domain, releasing the Notch intracellular domain (NICD) to translocate to the nucleus. Subsequent signal transduction then occurs through either the CSL-NICD-Mastermind complex cascade (canonical pathway), or NF-kappaB-NICD and CSL-NICD-Deltex complex signalling cascades (non-canonical pathway). The canonical pathway inhibits the differentiation of stem cells or progenitor cells, whilst the non-canonical pathway promotes differentiation. Jagged1 signalling is implicated in cell-fate decisions during haematopoiesis, as well as in both early and late stages of mammalian cardiovascular development, and is involved in the inhibition of myoblast differentiation. Studies have shown a significant increase in the expression of Jagged1 in metastatic prostate cancer, compared with localized prostate cancer or benign prostatic tissues, implicating Jagged1 as a biomarker to facilitate their differentiation. In humans, mutations in the JAG1 gene are responsible for the autosomal dominant multi-system developmental disorder known as Alagille syndrome type 1 (ALGS1), and also for the congenital heart anomaly tetralogy of Fallot (TOF). Clone HMJ1-29 has been shown to cross-react with rat mast cell line RBL-2H3 and Y3 myeloma cells, in flow cytometry.


PBS, 0.09% sodium azide
+4°C or -20°C, Avoid repeated freezing and thawing.
For research use only.

About JAG1 / Jagged 1

P78504 NM_000214 NP_000205.1

JAG1 Antibody, AGS Antibody, AHD Antibody, Alagille syndrome Antibody, CD339 antigen Antibody, HJ1 Antibody, Jagged1 Antibody, JAGL1 Antibody, Jagged Antibody, Jagged 1 Antibody, Protein jagged-1 Antibody, AWS Antibody, CD339 Antibody, Soluble protein jagged Antibody

Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro).

Requested From: United States
Date Requested: 10/24/2016

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