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Anti-IVL / Involucrin Antibody (clone SY5) IHC-plus™ LS-B6298

Note: This antibody replaces LS-C11369


Wt. Vol. Conc. Price
50 µg - 0.5 mg/ml $395
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)

Most Popular IVL / Involucrin Antibodies

Anti-IVL / Involucrin Antibody (clone SY5) IHC-plus™ LS-B6298
Mouse Monoclonal [clone SY5] (IgG1) to Human IVL / Involucrin
Human, Monkey, Dog, Pig
IHC - Paraffin, IHC - Frozen, Western blot, Immunoprecipitation, ELISA
Immunohistochemistry Image
Anti-IVL / Involucrin Antibody (aa301-460) LS-C294948
Rabbit Polyclonal (IgG) to Mouse IVL / Involucrin
Western blot, ELISA
Western blot Image

100% Guaranteed 100% Guaranteed
Mouse Monoclonal [clone SY5] (IgG1) to Human IVL / Involucrin
Human, Monkey, Dog, Pig
IHC - Paraffin, IHC - Frozen, Western blot, Immunoprecipitation, ELISA


Human IVL / Involucrin
Human, Monkey, Dog, Pig (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [SY5]
Protein A purified


  • IHC - Paraffin (10 µg/ml)
  • IHC - Frozen
  • Western blot
  • Immunoprecipitation

Specificity and Use

IVL / Involucrin antibody was raised against native, from keratinocytes.
Recognizes human involucrin, a 585 amino acid soluble protein encoded by the IVL gene and expressed in epidermal keratinocytes as they tend towards terminal differentiation. Involucrin is produced in the stratum spinosum initially in the cell cytosol from where it moves to the cell membrane, associates with transglutaminase and becomes cross-linked to membrane proteins, offering structural support to the cell and forming a stable envelope below the plasma membrane. Recognizes an epitope between residues 421-568 of human involucrin. Involucrin expression is seen in the normal granular cells of the epidermis associated with the plasma membrane during the early phase of cornified envelope maturation and expression is increased in psoriatic epidermis with abnormal cornified envelope maturation. Involucrin staining is also maintained, associated with the cornified envelope in epidermolytic hyperkeratosis, a condition associated with mutations to mutations in genes coding for cytokeratins 1 and 10.


PBS, 0.09% sodium azide. Sourced in TCS.
Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
For research use only.

About IVL / Involucrin

P07476 NM_005547 NP_005538.2

IVL Antibody, Involucrin Antibody

Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.


Anti-IVL / Involucrin antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6298 concentration 10 ug/ml.

Requested From: United States
Date Requested: 10/22/2016

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