Human, Gorilla, Dog, Pig
(tested or 100% immunogen sequence identity)
Also available Unmodified
Purified Involucrin from human keratinocytes.
The applications listed have been tested for the unmodified form of this product. Other forms have not been tested. Involucrin is expressed in a range of stratified squamous epithelia, including the cornea, which lacks a distinct cornified layer. In normal epidermis, it is first expressed in the upper spinous layers, and in keratinocyte cultures, all cells that have left the basal layer express it. Involucrin expression is altered in pathological conditions: in psoriasis and other benign epidermal hyperplasias, involucrin expression begins closer to the basal layer than normal. expression is abnormal in squamous cell carcinomas and premalignant lesions, and is reduced in severe dysplasias of the larynx and cervix. The optimal dilution of the Involucrin antibody for each application should be determined by the researcher. Staining of formalin-fixed tissues is enhanced by digestion with Trypsin or Protease XXV at 1mg/ml PBS for 5 min at 37oC. Enzyme digestion is better than citrate buffer based epitope unmasking.
This antibody carries the LSBio 100% Guarantee.