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ITSN1 / ITSN

intersectin 1 (SH3 domain protein)

Acts as guanine nucleotide exchange factor (GEF) specific for the CDC42 GTPase (By similarity). Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1.

Gene Name: intersectin 1 (SH3 domain protein)
Synonyms: ITSN1, Intersectin 1, ITSN, Intersectin-1, Intersectin short variant 12, SH3P17, SH3D1A
Target Sequences: NM_003024 NP_003015.2 Q15811

Publications (1)

1
Cytoskeletal regulation by AUTS2 in neuronal migration and neuritogenesis. Hori K, Nagai T, Shan W, Sakamoto A, Taya S, Hashimoto R, Hayashi T, Abe M, Yamazaki M, Nakao K, Nishioka T, Sakimura K, Yamada K, Kaibuchi K, Hoshino M. Cell reports. 2014 9:2166-79. (WB; Mouse) [Full Text Article] [PubMed:25533347]

☰ Filters
Antibodies (12)
Proteins (4)
Over-Expression Lysate (2)
Primary (12)
Recombinant (2)
ITSN1 / ITSN (16)
Human (4)
Mouse (9)
Rat (9)
WB (12)
ELISA (2)
IF (1)
IP (1)
Peptide-ELISA (1)
rabbit (11)
mouse (1)
IgG (2)
IgG2b,k (1)
monoclonal mc (1)
polyclonal pc (11)
2F12 (1)
APC (1)
APC Conjugated (1)
Biotin Conjugated (1)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (1)
HRP Conjugated (1)
PE Conjugated (1)
Unconjugated (5)
aa1-227 (8)
aa646-840 (1)
aa850-900 (1)
No (16)
GST, N-terminus (1)
His-T7 (1)
Myc-DDK (Flag) (2)
Human (2)
Rat (1)
293T Cells (1)
E. coli (1)
HEK 293 Cells (1)
Wheat Germ Extract (1)
Select
ITSN1 / ITSN Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
ITSN1 / ITSN Antibody - Western blot of ITSN1 / ITSN antibody with recombinant ITSN1 encoding aa 1-227 of rat ITSN1.
Select
ITSN1 / ITSN Rabbit anti-Rat Polyclonal (aa1-227) Antibody
Mouse, Rat
WB
Unconjugated
100 µl/$317; 200 µl/$363; 500 µl/$515; 1 ml/$591; 2 ml/$816; 5 ml/$1,331
ITSN1 / ITSN Antibody - Western blot of ITSN1 / ITSN antibody with recombinant ITSN1 encoding aa 1-227 of rat ITSN1.
Select
ITSN1 / ITSN Rabbit anti-Rat Polyclonal (aa1-227) (HRP) Antibody
Mouse, Rat
WB
HRP Conjugated
100 µl/$349; 200 µl/$408; 500 µl/$609; 1 ml/$762; 2 ml/$999; 5 ml/$1,729
ITSN1 / ITSN Antibody - Western blot of ITSN1 / ITSN antibody with recombinant ITSN1 encoding aa 1-227 of rat ITSN1.
Select
ITSN1 / ITSN Rabbit anti-Rat Polyclonal (aa1-227) (Biotin) Antibody
Mouse, Rat
WB
Biotin Conjugated
100 µl/$328; 200 µl/$378; 500 µl/$545; 1 ml/$645; 2 ml/$879; 5 ml/$1,464
ITSN1 / ITSN Antibody - Western blot of ITSN1 / ITSN antibody with recombinant ITSN1 encoding aa 1-227 of rat ITSN1.
Select
ITSN1 / ITSN Rabbit anti-Rat Polyclonal (aa1-227) (FITC) Antibody
Mouse, Rat
WB
FITC Conjugated
100 µl/$359; 200 µl/$423; 500 µl/$655; 1 ml/$816; 2 ml/$1,055; 5 ml/$1,863
ITSN1 / ITSN Antibody - Western blot of ITSN1 / ITSN antibody with recombinant ITSN1 encoding aa 1-227 of rat ITSN1.
Select
ITSN1 / ITSN Rabbit anti-Rat Polyclonal (aa1-227) (APC, Cy7) Antibody
Mouse, Rat
WB
APC, Cy7 Conjugated
100 µl/$530; 200 µl/$703; 500 µl/$1,217; 1 ml/$1,521; 2 ml/$2,129; 5 ml/$3,991
ITSN1 / ITSN Antibody - Western blot of ITSN1 / ITSN antibody with recombinant ITSN1 encoding aa 1-227 of rat ITSN1.
Select
ITSN1 / ITSN Rabbit anti-Rat Polyclonal (aa1-227) (Cy3) Antibody
Mouse, Rat
WB
Cy3 Conjugated
100 µl/$423; 200 µl/$515; 500 µl/$906; 1 ml/$1,071; 2 ml/$1,420; 5 ml/$2,661
ITSN1 / ITSN Antibody - Western blot of ITSN1 / ITSN antibody with recombinant ITSN1 encoding aa 1-227 of rat ITSN1.
Select
ITSN1 / ITSN Rabbit anti-Rat Polyclonal (aa1-227) (APC) Antibody
Mouse, Rat
WB
APC Conjugated
100 µl/$423; 200 µl/$515; 500 µl/$906; 1 ml/$1,071; 2 ml/$1,420; 5 ml/$2,661
ITSN1 / ITSN Antibody - Western blot of ITSN1 / ITSN antibody with recombinant ITSN1 encoding aa 1-227 of rat ITSN1.
Select
ITSN1 / ITSN Rabbit anti-Rat Polyclonal (aa1-227) (PE) Antibody
Mouse, Rat
WB
PE Conjugated
100 µl/$423; 200 µl/$515; 500 µl/$906; 1 ml/$1,071; 2 ml/$1,420; 5 ml/$2,661
ITSN1 / ITSN Antibody - Detection limit for recombinant GST tagged ITSN1 is 0.03 ng/ml as a capture antibody.
Select
ITSN1 / ITSN Mouse anti-Human Monoclonal (2F12) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
ITSN1 / ITSN Antibody
Select
ITSN1 / ITSN Rabbit anti-Human Polyclonal (aa646-840) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$332
Select
ITSN1 / ITSN Rabbit anti-Human Polyclonal (aa850-900) Antibody
Human
IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
ITSN1 / ITSN Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
ITSN1 / ITSN Protein - Recombinant  Intersectin 1 By SDS-PAGE
Select
E. coli
His-T7
27.6 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
Select
293T Cells
Myc-DDK (Flag)
195.9 kDa
20 µg/$215
Select
HEK 293 Cells
Myc-DDK (Flag)
195.9 kDa
100 µg/$710
Viewing 1-16 of 16 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).