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Anti-ITPR1 / IP3 Receptor Type 1 Antibody (aa1892-1911) IHC-plus™ LS-B2640

Note: This antibody replaces LS-C8244


Wt. Vol. Conc. Price
- 50 µl 1.3 mg/ml Unavailable

Most Popular ITPR1 / IP3 Receptor Type 1 Antibodies

Anti-ITPR1 / IP3 Receptor Type 1 Antibody (clone S24-18) IHC-plus™ LS-B8161
Mouse Monoclonal [clone S24-18] (IgG1)
Human, Mouse, Rat
IHC - Paraffin, Western blot, Immunoprecipitation
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed Publications Publications (1)
Rabbit Polyclonal (IgG) to Human ITPR1 / IP3 Receptor Type 1
Human, Monkey, Mouse, Rat, Bovine
IHC - Paraffin, IHC - Frozen, ICC, Western blot, Immunoprecipitation


Human ITPR1 / IP3 Receptor Type 1
Human, Monkey, Mouse, Rat, Bovine (tested or 100% immunogen sequence identity)
Hamster, Horse (at least 90% immunogen sequence identity)
IgG Polyclonal
Affinity purified


  • IHC - Paraffin (5 µg/ml)
  • IHC - Frozen (1:125)
  • ICC
  • Western blot (1:500)
  • Immunoprecipitation

Specificity and Use

ITPR1 / IP3 Receptor Type 1 antibody was raised against synthetic peptide corresponding to aa 1892-1911 (N1892KKKDDEVDRDAPSRKKAKE1911) of the cytoplasmic C-terminal domain of human IP3R-I (inositol 1,4,5-triphosphate receptor (type-I)). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Bovine (100%); Hamster, Elephant, Panda, Horse (95%); Opossum (85%).
Recognizes human IP3R-I. Detects a band of ~240kD by Western Blot. Species cross-reactivity: mouse, rat and canine.
Immunohistochemistry: LS-B2640 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B2640 was determined to be 5 ug/ml.


PBS, 1 mg/ml BSA, 0.05% sodium azide.
+4°C or -20°C, Avoid repeated freezing and thawing.
For research use only.

Publications (1)

PC-PLC is involved in osteoclastogenesis induced by TNF- alpha through upregulating IP3R1 expression. Xia L, Zhang D, Wang C, Wei F, Hu Y. FEBS letters. 2012 Sep;586:3341-8. [Full Text Article] [PubMed:22819818]

About ITPR1 / IP3 Receptor Type 1

Q14643 NM_001099952 NP_002213.5

ITPR1 Antibody, InsP3R-I Antibody, IP3R1 Antibody, InsP3R Antibody, InsP3R type I Antibody, INSP3R1 Antibody, IP3R Antibody, Opisthotonus Antibody, Pcp1 Antibody, IP3 receptor Antibody, IP3 receptor isoform 1 Antibody, SCA15 Antibody, Spinocerebellar ataxia 15 Antibody, Spinocerebellar ataxia 16 Antibody, I145TR Antibody, IP3R 1 Antibody, KIAA1754 Antibody, SCA16 Antibody, Type 1 InsP3 receptor Antibody

This gene encodes an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in this gene cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. Multiple transcript variants have been identified for this gene.


Anti-ITPR1 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2640 concentration 5 ug/ml.

Requested From: 
Date Requested: 3/22/2017

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