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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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ITGB4 / Integrin Beta 4 Antibody (RPE) LS‑C44755
Note: This antibody replaces LS-C57924
Antibody
Integrin Beta 4 antibody LS-C44755 is an RPE-conjugated rat monoclonal antibody to mouse Integrin Beta 4 (ITGB4). Validated for Flow, IHC, IP and WB.
Catalog
Size
Price
LS-C44755-100
100 tst
Unavailable

Popular ITGB4 / Integrin Beta 4 Products

Antibody
Species: Human
Applications: IHC, IHC - Frozen, Western blot, Immunoprecipitation, Flow Cytometry
Antibody
Species: Human
Applications: ICC, Western blot, Flow Cytometry, ELISA
Human colon carcinoma cell line (HT29) stained with purified 58XB4, followed by anti-mouse IgG FITC
Species: Human
Applications: IHC, IHC - Frozen, Immunoprecipitation, Flow Cytometry
Staining of human tonsil cryostat section with Mouse anti-human CD104 (LS-C43630).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Species: Human, Ferret, Mustelid
Applications: IHC, IHC - Frozen, Western blot, Immunoprecipitation, Flow Cytometry
Anti-Integrin Beta 4 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3778 concentration 20 ug/ml.
Species: Human
Applications: IHC, IHC - Paraffin, IHC - Frozen, Western blot, Flow Cytometry

Product Description

Integrin Beta 4 antibody LS-C44755 is an RPE-conjugated rat monoclonal antibody to mouse Integrin Beta 4 (ITGB4). Validated for Flow, IHC, IP and WB.
About ITGB4 / Integrin Beta 4
Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. P16144 NM_000213 NP_000204.3

ITGB4 Antibody, CD104 Antibody, Integrin beta-4 Antibody, Integrin Beta 4 Antibody, gp150 Antibody, CD104 antigen Antibody, Integrin beta-4 subunit Antibody, Integrin, beta 4 Antibody


Specifications

Target
Mouse ITGB4 / Integrin Beta 4
Host
Rat
Reactivity
Mouse (tested or 100% immunogen sequence identity)
Clonality
IgG2a Monoclonal
Conjugations
R. Phycoerythrin. Also available Unconjugated or conjugated with Biotin, FITC.
Purification
Protein G purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Frozen
  • Western blot
  • Immunoprecipitation
  • Flow Cytometry (1:1 - 1:5)
  • (applications tested for the base form of this product only)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
TSP-180 purified from Balb/c murine carcinoma.
Specificity
Recognizes mouse integrin beta 4 (CD104), a 200kD glycoprotein that can associate with integrin alpha 6 (CD49f) to form a heterodimer on the cell surface. Expression of CD104 is localized to the basal region of a wide variety of epithelial cells. In mice, CD104 is also expressed on peripheral neurons, carcinoma cell lines and a subset of endothelial cells. The alpha 6 beta 4 (CD49f/CD104) integrin has been identified as a component of hemidesmosomes in stratified squamous epithelium where it plays an important role in the adhesion of epithelia to basement membrane. Studies suggest that the CD49f/CD104 integrin is involved in cell matrix adhesion but expression of the CD49f/CD104 integrin in endothelial cells is thought to have a different function.
Usage
The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested. Flow Cytometry: Use 10 ul of the suggested working dilution to label 10^6 cells in 100 ul Method sheets are available on request.
Presentation
Lyophilized, PBS, pH 7.4, 0.09% sodium azide, 1% BSA.
Reconstitution
100 tst Distilled Water.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: 
Date Requested: 6/19/2018

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