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Anti-ITGB3 / Integrin Beta 3 / CD61 Antibody (clone PM6/13) LS-C11659

Note: This antibody replaces LS-C58642, LS-C45301

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Mouse Monoclonal [clone PM6/13] (IgG1) to Human ITGB3 / Integrin Beta 3 / CD61
Human, Baboon, Ferret, Goat, Mustelid
IHC - Frozen, Western blot, Immunoprecipitation, Flow Cytometry
Unconjugated

Details

Human ITGB3 / Integrin Beta 3 / CD61
Mouse
Human, Baboon, Ferret, Goat, Mustelid (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [PM6/13]
Protein A purified

Applications

IHC - Frozen, Western blot, Immunoprecipitation, Flow Cytometry (1:100 - 1:200)

Specificity and Use

ITGB3 / Integrin Beta 3 / CD61 antibody was raised against platelet plasma membrane.
Recognizes CD61, a 105kD glycoprotein, which is also known as integrin beta 3 chain. This molecule associates with either the alpha IIb integrin (CD41) or the alpha V integrin (CD51) at the cell surface. CD61 is expressed on platelets and megakaryocytes in association with CD41, and on endothelial cells, monocytes, platelets and osteoclasts in association with CD51. CD61 is a receptor for fibrinogen, fibronectin, vWF, vitronectin and thrombospondin. This clone inhibits platelet aggregation and activation induced by thrombin and collagen. Removal of sodium azide is recommended prior to use in functional assays. XXX recommend the use of EQU003 for this purpose.
Flow Cytometry: Use 10 ul of the suggested working dilution to label 10^6 cells or 100 ul whole blood. Method sheets are available on request.

Packaging

PBS, pH 7.4, 0.09% sodium azide.
For research use only.

About ITGB3 / Integrin Beta 3 / CD61

P05106 NM_000212 NP_000203.2

ITGB3 Antibody, BDPLT2 Antibody, CD61 antigen Antibody, GT Antibody, gp3A Antibody, CD61 Antibody, GPIIIa Antibody, Integrin beta-3 Antibody

Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands.

Requested From: United States
Date Requested: 9/28/2016

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