Mouse ITGB3 / Integrin Beta 3 / CD61

Hamster

Mouse (tested or 100% immunogen sequence identity)

IgG Monoclonal

HM beta 3.1

Unconjugated. Also available conjugated with FITC, RPE.

Protein G purified

Unmodified

Mouse alpha 5 beta 3 protein purified from the mouse hybridoma 2B4

Recognizes the murine integrin beta 3 subunit (CD61), a 90kD a type I membrane protein, which is expressed primarily on megakaryocytes, platelets, monocytes, macrophages, granulocytes and endothelial cells. CD61 associates with either the alpha IIb integrin (CD41) or the alpha V integrin (CD51) to form the platelet glycoprotein complex IIb/IIIa and the vitronectin receptor (VNR) respectively. The heterodimers formed with CD61 are receptor for a variety of ligands including fibrinogen, fibronectin, von Willebrand's factor (vWF), vitronectin and thrombospondin. Clone HM beta 3-1 is reported to partially inhibit the binding of CD61 to fibronectin.

• Immunoprecipitation
• Flow Cytometry (1:10 - 1:25)

Flow Cytometry: Use 10 ul of the suggested working dilution to label 10^6 cells in 100 ul. Method sheets are available on request.

PBS, 0.09% Sodium Azide

Store at 4°C or at -20°C. Store undiluted. Avoid freeze/thaw cycles.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P05106 NCBI: NM_000212 NP_000203.2