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ITGAV/Integrin Alpha V/CD51

integrin, alpha V

ITGAV/Integrin Alpha V/CD51 is a protein that is a member of the integrin superfamily. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein undergoes post-translational cleavage to yield disulfide-linked heavy and light chains that combine with multiple integrin beta chains to form different integrins. This protein has been shown to heterodimerize with beta 1, beta 3, beta 5, beta 6, and beta 8; the heterodimer of alpha v and beta 3 is the Vitronectin receptor. This protein interacts with several extracellular matrix proteins to mediate cell adhesion and may play a role in cell migration. It is proposed that this protein may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants that encode different protein isoforms. Note that the integrin alpha 5 and integrin alpha V chains are produced by distinct genes.

Gene Name: integrin, alpha V
Family/Subfamily: Integrin , not assigned-Integrin
Synonyms: ITGAV, CD51, CD51 antigen, Integrin, alpha V, MSK8, Integrin Alpha V, Integrin alpha-V, VNRA, Vitronectin receptor, Integrin alphaVbeta3, VTNR
Target Sequences: NM_002210 NP_002201.1 P06756

Publications (5)

1
Differential distribution and modulation of expression of alpha 1/beta 1 integrin on human endothelial cells. Defilippi P, van Hinsbergh V, Bertolotto A, Rossino P, Silengo L, Tarone G. The Journal of cell biology. 1991 114:855-63. [PubMed:1869591] [PMC:PMC2289904]
2
Colon carcinoma cell glycolipids, integrins, and other glycoproteins mediate adhesion to HUVECs under flow. Burdick MM, McCaffery JM, Kim YS, Bochner BS, Konstantopoulos K. American journal of physiology. Cell physiology. 2003 284:C977-87. [PubMed:12477667]
3
Molecular magnetic resonance imaging of angiogenesis in vivo using polyvalent cyclic RGD-iron oxide microparticle conjugates. Melemenidis S, Jefferson A, Ruparelia N, Akhtar AM, Xie J, Allen D, Hamilton A, Larkin JR, Perez-Balderas F, Smart SC, Muschel RJ, Chen X, Sibson NR, Choudhury RP. Theranostics. 2015 5:515-29. (IP; Mouse) [Full Text Article] [PubMed:25767618] [PMC:PMC4350013] Related Antibodies: LS-C57970.
4
Pulmonary pericytes regulate lung morphogenesis. Kato K, Diéguez-Hurtado R, Park DY, Hong SP, Kato-Azuma S, Adams S, Stehling M, Trappmann B, Wrana JL, Koh GY, Adams RH. Nature communications. 2018 June;9:2448. (Mouse) [Full Text Article] [PubMed:29934496] [PMC:PMC6015030] Related Antibodies: LS-C57970.
5
Tumour exosome integrins determine organotropic metastasis. Hoshino A, Costa-Silva B, Shen TL, Rodrigues G, Hashimoto A, Tesic Mark M, Molina H, Kohsaka S, Di Giannatale A, Ceder S, Singh S, Williams C, Soplop N, Uryu K, Pharmer L, King T, Bojmar L, Davies AE, Ararso Y, Zhang T, Zhang H, Hernandez J, Weiss JM, Dumont-Cole VD, Kramer K, Wexler LH, Narendran A, Schwartz GK, Healey JH, Sandstrom P, Labori KJ, Kure EH, Grandgenett PM, Hollingsworth MA, de Sousa M, Kaur S, Jain M, Mallya K, Batra SK, Jarnagin WR, Brady MS, Fodstad O, Muller V, Pantel K, Minn. Nature. 2015 November;527:329-35. [Full Text Article] [PubMed:26524530] [PMC:PMC4788391]
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ITGAV/Integrin Alpha V/CD51 Rat anti-Mouse Monoclonal (RMV-7) Antibody
Mouse
Flo, IHC, IHC-Fr, IP
Unconjugated
0.25 mg/$471
ITGAV/Integrin Alpha V/CD51 Antibody - Anti-CD51 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
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ITGAV/Integrin Alpha V/CD51 Rabbit anti-Human Polyclonal (aa840-889) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
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ITGAV/Integrin Alpha V/CD51 Rat anti-Mouse Monoclonal (Low Endotoxin) (RMV-7) Antibody
Mouse
Flo, IP
Unconjugated, Low Endotoxin
0.5 mg/$671
ITGAV/Integrin Alpha V/CD51 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$798
ITGAV/Integrin Alpha V/CD51 Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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ITGAV/Integrin Alpha V/CD51 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
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ITGAV/Integrin Alpha V/CD51 Mouse anti-Human Monoclonal (NKI-M7 (former AMF7)) Antibody
Human
ELISA, Flo, IHC, IHC-Fr, IP
Unconjugated
0.1 mg/$424
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ITGAV/Integrin Alpha V/CD51 Mouse anti-Human Monoclonal (Biotin) Antibody
Human
Flo, IHC, IHC-Fr, IP
Biotin Conjugated
100 µg/$626
ITGAV/Integrin Alpha V/CD51 Antibody - Western Blot; Sample: Lane1: Human A549 Cells; Lane2: Human Hela Cells.
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ITGAV/Integrin Alpha V/CD51 Rabbit anti-Mouse Polyclonal (aa71-322) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
ITGAV/Integrin Alpha V/CD51 Antibody - Immunohistochemistry image of paraffin-embedded human glioma cancer at a dilution of 1:100
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ITGAV/Integrin Alpha V/CD51 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
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ITGAV/Integrin Alpha V/CD51 Mouse anti-Human Monoclonal Antibody
Human
Flo, ICC, IHC, IP
Unconjugated
100 µg/$872
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ITGAV/Integrin Alpha V/CD51 Mouse anti-Human Monoclonal (HRP) Antibody
Human
Flo, ICC, IHC
HRP Conjugated
100 µl/$1,089
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ITGAV/Integrin Alpha V/CD51 Mouse anti-Human Monoclonal (Biotin) Antibody
Human
Flo, ICC, IHC
Biotin Conjugated
100 µl/$1,089
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ITGAV/Integrin Alpha V/CD51 Mouse anti-Human Monoclonal (FITC) Antibody
Human
Flo, ICC, IHC
FITC Conjugated
100 µl/$1,089
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ITGAV/Integrin Alpha V/CD51 Mouse anti-Human Monoclonal (PE) Antibody
Human
Flo, ICC, IHC
PE Conjugated
100 µl/$1,089
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ITGAV/Integrin Alpha V/CD51 Mouse anti-Human Monoclonal (APC) Antibody
Human
Flo, ICC, IHC
APC Conjugated
100 µl/$1,089
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ITGAV/Integrin Alpha V/CD51 Mouse anti-Human Monoclonal Antibody
Human
Flo, ICC, IHC, IP
Unconjugated
100 µg/$866
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ITGAV/Integrin Alpha V/CD51 Rat anti-Mouse Monoclonal (RMV-7) Antibody
Mouse
Flo, IHC, IHC-Fr, IP
Unconjugated
100 µg/$597; 250 µg/$807
ITGAV/Integrin Alpha V/CD51 Protein - Recombinant Integrin Alpha V By SDS-PAGE
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E. coli
His, N-Terminal
24.0 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
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ITGAV/Integrin Alpha V/CD51 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Goat, Sheep, Pig, Horse, Human
ELISA, IHC, IHC-Fr, IP, RIA, WB
Unconjugated
100 µl/$826
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ITGAV/Integrin Alpha V/CD51 Mouse anti-Human Monoclonal (FITC) (P2W7) Antibody
Human
Flo
FITC Conjugated
120 Tests/$446
ITGAV/Integrin Alpha V/CD51 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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ITGAV/Integrin Alpha V/CD51 Rabbit anti-Human Polyclonal (aa755-804) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100 µl/$515
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ITGAV/Integrin Alpha V/CD51 Mouse-Balb/c anti-Human Monoclonal (NKI-M9 (former PAF2a)) Antibody
Human
ELISA, Flo, IF, IHC, IHC-Fr, IP
Unconjugated
0.1 mg/$424
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ITGAV/Integrin Alpha V/CD51 Mouse anti-Human Monoclonal Antibody
Human
Flo, IHC, IHC-Fr, IP
Unconjugated
100 µg/$558
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ITGAV/Integrin Alpha V/CD51 Mouse anti-Human Monoclonal (Concentrated) (23C6) Antibody
Human
Flo, IHC, IHC-Fr, IP
Unconjugated, Concentrated
0.2 mg/$735
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ITGAV/Integrin Alpha V/CD51 Mouse anti-Human Monoclonal Antibody
Human
IF, IHC, IP
Unconjugated
100 µl/$801
Viewing 1-25 of 99 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).