Mouse ITGAV/Integrin Alpha V/CD51

Rat

Mouse (tested or 100% immunogen sequence identity)

IgG1 Monoclonal

RMV-7

Unconjugated

Affinity purified

Unmodified. Also available Low Endotoxin.

Cultured LAK cells from Balb/c mice

Recognizes murine CD51, a 140 kD alpha subunit of the vitronectin receptor, which is otherwise known as the integrin alpha v chain. CD51 can form heterodimers at the cell surface with a variety of beta integrins including CD29 and CD61. Heterodimers of CD51/CD61 function as a receptor for vitronectin, and a wide array of RGD-containing proteins including fibronectin, fibrinogen, von Willebrand factor, laminin, thrombospondin and osteopontin. CD51/CD61 is primarily expressed on myeloid cells and activated T-cells. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing. The RMV-7 antibody has been reported to block binding of CD51 to vitronectin, fibronectin, and CD31 in some cell types, as well as blocking LAK cell cytotoxicity.

• IHC
• IHC - Frozen (1:25 - 1:100)
• Immunoprecipitation
• Flow Cytometry (1:25 - 1:100)

Flow Cytometry: Use 10 ul of the suggested working dilution to label 10^6 cells in 100 ul. Method sheets are available on request.

PBS, 0.09% Sodium Azide

Short term: store at 4°C. Long term: aliquot and store at -20°C. Avoid freeze-thaw cycles.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P06756 NCBI: NM_002210 NP_002201.1