Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Rabbit Polyclonal (IgG) to Human ITGAV/Integrin Alpha V/CD51
IHC, IHC - Paraffin, Western blot, Peptide Enzyme-Linked Immunosorbent Assay
Mouse Monoclonal [clone NKI-M9] (IgG1) to Human ITGAV/Integrin Alpha V/CD51
Human ITGAV/Integrin Alpha V/CD51
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [NKI-M9]
Specificity and Use
Ascites fluid of tumor bearing BALB/c mice.
This antibody is directed against the CD51 antigen, which can form distinct complexes with: the CD61 antigen resulting in the alpha-beta 3 complex, which is expressed on human platelets; the beta5 integrin, resulting in the alpha-beta5 complex, which is expressed on human monocytes and macrophages; and the beta1 integrin, resulting in the alpha-beta1 complex. Also reacts with megakaryocytes and some B cells (1).
20 mM Tris, pH 8.0, 150 mM sodium chloride, 10 mg BSA
ITGAV/Integrin Alpha V/CD51 is a protein that is a member of the integrin superfamily. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein undergoes post-translational cleavage to yield disulfide-linked heavy and light chains that combine with multiple integrin beta chains to form different integrins.