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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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ITGAM / CD11b Antibody (clone MEM‑174, Azide‑free) LS‑C45699
Antibody
CD11b antibody LS-C45699 is an unconjugated mouse monoclonal antibody to human CD11b (ITGAM). Validated for Flow and IP.
Catalog
Size
Price
LS-C45699-100
100 µg
Unavailable

Popular ITGAM / CD11b Products

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Product Description

CD11b antibody LS-C45699 is an unconjugated mouse monoclonal antibody to human CD11b (ITGAM). Validated for Flow and IP.
About ITGAM / CD11b
Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. P11215 NM_000632 NP_000623.2

ITGAM Antibody, Antigen CD11b (p170) Antibody, CD11B Antibody, CD11b antigen Antibody, CR3A Antibody, Integrin alpha-M Antibody, MAC-1 Antibody, MO1A Antibody, Neutrophil adherence receptor Antibody, MAC1A Antibody, SLEB6 Antibody, CR-3 alpha chain Antibody


Specifications

Target
Human ITGAM / CD11b
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG2a Monoclonal [MEM-174]
Conjugations
Unconjugated
Purification
Protein A purified
Modifications
Azide-free
Applications
  • Immunoprecipitation
  • Flow Cytometry
Failed Applications
  • IHC - Paraffin
Immunogen
ITGAM / CD11b antibody was raised against human granulocytes.
Specificity
Recognizes CD11b antigen (Mac-1), a 165 kD type 1 transmembrane protein mainly expressed on monocytes, granulocytes and NK-cells. The CD11b mediates neutrophil and monocyte interactions with stimulated endothelium.
Usage
Flow Cytometry: Recommended dilution - 1 ug/ml. Positive control - Peripheral Blood Lymphocytes. Immunoprecipitation: Positive control - Granulocytes. CD11b/CD18 transfectants. Application note - Immunoprecipitation with the antibody MEM-174 was successfu The applications listed have been tested for the unmodified form of this product. Other forms have not been tested.
Presentation
Azide free PBS, preserved by filter sterilization, approx., pH 7.4.
Storage
Short term 4°C, long term aliquot and store at -20°C, avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: 
Date Requested: 6/22/2018

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