Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Dissection of the hyperadhesive phenotype of airway eosinophils in asthma. Barthel SR, Jarjour NN, Mosher DF, Johansson MW. American journal of respiratory cell and molecular biology. 2006 35:378-86.
Functional heterogeneity and differential priming of circulating neutrophils in human experimental endotoxemia. Pillay J, Ramakers BP, Kamp VM, Loi AL, Lam SW, Hietbrink F, Leenen LP, Tool AT, Pickkers P, Koenderman L. Journal of leukocyte biology. 2010 88:211-20.
The Vi capsular polysaccharide prevents complement receptor 3-mediated clearance of Salmonella enterica serotype Typhi. Wilson RP, Winter SE, Spees AM, Winter MG, Nishimori JH, Sanchez JF, Nuccio SP, Crawford RW, Tkel, Bumler AJ. Infection and immunity. 2011 79:830-7.
Hax1 regulates neutrophil adhesion and motility through RhoA. Cavnar PJ, Berthier E, Beebe DJ, Huttenlocher A. The Journal of cell biology. 2011 193:465-73.
Infection of dendritic cells with herpes simplex virus type 1 induces rapid degradation of CYTIP, thereby modulating adhesion and migration. Theodoridis AA, Eich C, Figdor CG, Steinkasserer A. Blood. 2011 118:107-15.
Human eosinophils express RAGE, produce RAGE ligands, exhibit PKC-delta phosphorylation and enhanced viability in response to the RAGE ligand, S100B. Curran CS, Bertics PJ. International immunology. 2011 23:713-28.
Human suppressive neutrophils CD16bright/CD62Ldim exhibit decreased adhesion. Kamp VM, Pillay J, Lammers JW, Pickkers P, Ulfman LH, Koenderman L. Journal of leukocyte biology. 2012 92:1011-20.
Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.