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Anti-ITGAD / CD11d Antibody (clone CA11.8H2) LS-C188176

Catalog Size Price
LS-C188176-2000 2000 µl Unavailable

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100% Guaranteed
Mouse Monoclonal [clone CA11.8H2] (IgG1) to Dog ITGAD / CD11d
IHC - Frozen, Immunoprecipitation, Flow Cytometry


Dog ITGAD / CD11d
Dog (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [CA11.8H2]
Tissue culture supernatant


  • IHC - Frozen (1:10)
  • Immunoprecipitation
  • Flow Cytometry (1:1)

  • IHC - Paraffin

Specificity and Use

ITGAD / CD11d antibody was raised against affinity purified CD11 antigen from canine spleen.
Recognizes the canine CD11d cell surface antigen, also known as integrin alpha d subunit. The alpha d integrin (CD11d) subunit is expressed as a heterodimer with beta 2 integrin (CD18). CD11d is expressed by a sub-population of macrophages, some CD8 positive T cells and by gamma/delta T cells in the splenic red pulp. Over expression of CD11d is noted in histiocytic disorders including hemophagocytic sarcoma, described as a proliferative disorder specifically of CD11+ macrophages with macrophages demonstrating marked. Previously, canine histiocytic sarcoma were described as originating entirely from interstitial dendritic cells. Cells from animals with canine hepatosplenic T cell lymphoma (HTSL) strongly express CD11d on malignant cells. Dogs normally demonstrate strong positivity for CD11d on large granular lymphocytes, macrophages and T cells in the splenic red pulp. CD11+ gamma/delta T cells constitute ~30% red pulp T cells despite their rarity in peripheral blood, suggesting a splenic red pulp origin of HTSL.


Tissue culture supernatant, 0.09% sodium azide
+4°C or -20°C, Avoid repeated freezing and thawing.
For research use only.

About ITGAD / CD11d

Q13349 U37028 AAB38547.1

ITGAD Antibody, ADB2 Antibody, CD11D Antibody, Integrin, alpha D Antibody, Leukointegrin alpha D Antibody, Leukointegrin alpha d chain Antibody, CD11d antigen Antibody, Integrin alpha-D Antibody

Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood.

Requested From: 
Date Requested: 3/16/2018

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