Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Rat Monoclonal [clone R1-2] (IgG2b) to Mouse ITGA4 / VLA-4 / CD49d
Mouse ITGA4 / VLA-4 / CD49d
Mouse (tested or 100% immunogen sequence identity)
IgG2b Monoclonal [R1-2]
Protein G purified
Flow Cytometry (1 µg/10E6 cells)
Specificity and Use
ITGA4 / VLA-4 / CD49d antibody was raised against peyers Patch HEV binding lymphoma line (TK1).
Anti-mouse CD49d monoclonal antibody reacts with a4 integrin, which helps to mediate cell-cell and cell-matrix interactions. A4 integrin combines with beta1 and beta7 integrin to form VLA-4 and LPAM-1 (Peyers patch homing receptor) respectively. VLA-4 is
ITGA4 encodes integrin alpha chain 4. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Although alpha 4 is variably cleaved to yield two unlinked chains, this cleavage is unnecessary for integrin assembly and function.