Rat ITGA4 / VLA-4 / CD49d

Mouse

Rat (tested or 100% immunogen sequence identity)

IgG2a Monoclonal

MRalpha4-1

Unconjugated

Protein G purified

Low Endotoxin

RBL-2H3 rat basophilic leukaemia cell line.

Recognizes rat CD49d, otherwise known as integrin alpha 4 chain/VLA-4, a 150kD type-1 transmembrane glycoprotein and member of the integrin alpha chain family, which acts as a receptor for fibronectin and CD106 (VCAM-1). CD49d is expressed broadly on T and B lymphocytes, monocytes, thymocytes, mast cells and dendritic cells and is involved in cell-cell interactions, mononuclear cell trafficking to sites of endothelial inflammation, and the adhesion of cells to the extracellular matrix. Clone MRalpha4-1 inhibits the in vitro and in vivo functions of CD49d. Studies have shown that in rat Peyers patches, clone MRalpha4-1 inhibits the rolling and adherence of lymphocytes to postcapillary venules (PCV), and significantly inhibits the transendothelial migration of T lymphocytes.

• Immunoprecipitation
• Flow Cytometry (1:10 - 1:100)

The applications listed have been tested for the unmodified form of this product. Other forms have not been tested.

PBS

Store at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P13612 NCBI: NM_000885 NP_000876.3