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Anti-ITGA4 / VLA-4 / CD49d Antibody (clone MRalpha4-1, Low Endotoxin) LS-C188415


Wt. Vol. Conc. Price
500 µg - 1 mg/ml $425
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)

Most Popular ITGA4 / VLA-4 / CD49d Antibodies

Anti-ITGA4 / VLA-4 / CD49d Antibody (C-Terminus) IHC-plus™ LS-A9388
Rabbit Polyclonal to Human ITGA4 / VLA-4 / CD49d
Human, Monkey, Mouse, Rat, Bat, Dog, Hamster, Pig, Rabbit
IHC - Paraffin
Immunohistochemistry Image
Anti-ITGA4 / VLA-4 / CD49d Antibody (Internal) IHC-plus™ LS-B3837
Rabbit Polyclonal to Human ITGA4 / VLA-4 / CD49d
Human, Mouse, Rat
IHC - Paraffin, Immunofluorescence, Western blot
Immunohistochemistry Image
Anti-ITGA4 / VLA-4 / CD49d Antibody (clone PS/2, Azide-free, Low Endotoxin) LS-C149732
Rat Monoclonal [clone PS/2] (IgG2b,k)
Human, Mouse
IHC - Frozen, Flow Cytometry, Inhibition
Unconjugated, Azide-free, Low Endotoxin

100% Guaranteed 100% Guaranteed
Mouse Monoclonal [clone MRalpha4-1] (IgG2a) to Rat ITGA4 / VLA-4 / CD49d
Immunoprecipitation, Flow Cytometry, Functional Assay (applications tested for the base form of this product only)
Unconjugated, Low Endotoxin


Rat ITGA4 / VLA-4 / CD49d
Rat (tested or 100% immunogen sequence identity)
IgG2a Monoclonal [MRalpha4-1]
Protein G purified
Low Endotoxin


  • Immunoprecipitation
  • Flow Cytometry (1:10 - 1:100)
  • Functional Assay
  • (applications tested for the base form of this product only)

Specificity and Use

ITGA4 / VLA-4 / CD49d antibody was raised against rBL-2H3 rat basophilic leukaemia cell line.
Recognizes rat CD49d, otherwise known as integrin alpha 4 chain/VLA-4, a 150kD type-1 transmembrane glycoprotein and member of the integrin alpha chain family, which acts as a receptor for fibronectin and CD106 (VCAM-1). CD49d is expressed broadly on T and B lymphocytes, monocytes, thymocytes, mast cells and dendritic cells and is involved in cell-cell interactions, mononuclear cell trafficking to sites of endothelial inflammation, and the adhesion of cells to the extracellular matrix. Clone MRalpha4-1 inhibits the in vitro and in vivo functions of CD49d. Studies have shown that in rat Peyers patches, clone MRalpha4-1 inhibits the rolling and adherence of lymphocytes to postcapillary venules (PCV), and significantly inhibits the transendothelial migration of T lymphocytes.
The applications listed have been tested for the base form of this product. Alternate forms, such as conjugated, azide-free, or ready-to-use, have not been tested.


Store at -20°C. Minimize freezing and thawing.
For research use only.

About ITGA4 / VLA-4 / CD49d

P13612 NM_000885 NP_000876.3

ITGA4 Antibody, 269C wild type Antibody, CD49D Antibody, IA4 Antibody, Integrin alpha-4 Antibody, Integrin alpha 4 Antibody, Integrin alpha-4 subunit Antibody, Integrin alpha-IV Antibody, VLA-4 Antibody, VLA-4 subunit alpha Antibody, CD49d antigen Antibody

ITGA4 encodes integrin alpha chain 4. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Although alpha 4 is variably cleaved to yield two unlinked chains, this cleavage is unnecessary for integrin assembly and function.

Flow Cytometry

Flow Cytometry
Flow cytometry of Rat peripheral blood lymphocytes with Mouse anti-Rat CD49d:Low Endotoxin

Requested From: United States
Date Requested: 10/22/2016

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