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ISG54 / IFIT2
interferon-induced protein with tetratricopeptide repeats 2
IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis.
| Gene Name: | interferon-induced protein with tetratricopeptide repeats 2 |
| Synonyms: | IFIT2, Cig42, GARG-39, IFI-54, IFI-54K, IFIT-2, ISG-54 K, IFI54, p54, Interferon-induced protein 54, ISG-54K, ISG54, G10P2 |
| Target Sequences: | M14660 AAA59191.1 P09913 |
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