IRS4

insulin receptor substrate 4

Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2.

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Products

Antibodies (22)

Proteins (5)

ELISA Kits (3)

Type

Competitive EIA (1)

Custom (2)

Over-Expression Lysate (2)

Primary (22)

Recombinant (3)

Target

IRS4 (30)

Reactivity

Human (14)

Mouse (10)

Pig (1)

Application

IHC (1)

WB (20)

ELISA (2)

IF (1)

IP (2)

Peptide-ELISA (2)

Host

rabbit (20)

mouse (1)

goat (1)

Isotype

IgG (4)

IgG1,k (1)

Clonality

monoclonal mc (1)

polyclonal pc (21)

Clone

5B9 (1)

Format

96-Well Strip Plate (3)

APC (2)

APC Conjugated (2)

Biotin Conjugated (2)

Cy3 Conjugated (2)

Cy7 Conjugated (2)

FITC Conjugated (2)

HRP Conjugated (2)

PE Conjugated (2)

Unconjugated (8)

Epitope

aa1207-1257 (1)

aa633-647 (1)

aa875-925 (1)

Publications

No (30)

Sample Type

Cell Culture Supernatants (1)

Cell Lysates (1)

Plasma (1)

Serum (1)

Tissue Homogenates (1)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Mouse (1)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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IRS4 Antibody (aa633-647) LS-C186534

Antibody:

IRS4 Goat anti-Mouse Polyclonal (aa633-647) Antibody

Reactivity:

Mouse

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µg/$503

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IRS4 Antibody (clone 5B9) LS-C198571

Antibody:

IRS4 Mouse anti-Human Monoclonal (5B9) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$423

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Human IRS4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80125

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

133.6 kDa

Price:

20 µg/$215

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IRS4 Antibody LS-C832600

Antibody:

IRS4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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IRS4 Antibody (aa1207-1257) LS-C762860

Antibody:

IRS4 Rabbit anti-Human Polyclonal (aa1207-1257) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

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IRS4 Antibody LS-C809735

Antibody:

IRS4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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IRS4 Antibody LS-C663456

Antibody:

IRS4 Rabbit anti-Mouse Polyclonal Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261

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IRS4 Antibody (HRP) LS-C712831

Antibody:

IRS4 Rabbit anti-Mouse Polyclonal (HRP) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$342; 200 µl/$398; 500 µl/$585; 1 ml/$722; 2 ml/$959; 5 ml/$1,639

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IRS4 Antibody (Biotin) LS-C688168

Antibody:

IRS4 Rabbit anti-Mouse Polyclonal (Biotin) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$321; 200 µl/$369; 500 µl/$527; 1 ml/$611; 2 ml/$842; 5 ml/$1,387

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IRS4 Antibody (FITC) LS-C695083

Antibody:

IRS4 Rabbit anti-Mouse Polyclonal (FITC) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$352; 200 µl/$412; 500 µl/$622; 1 ml/$777; 2 ml/$1,014; 5 ml/$1,765

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IRS4 Antibody (Cy3) LS-C703808

Antibody:

IRS4 Rabbit anti-Mouse Polyclonal (Cy3) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Cy3 Conjugated

Price:

100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521

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IRS4 Antibody (APC) LS-C741220

Antibody:

IRS4 Rabbit anti-Mouse Polyclonal (APC) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

APC Conjugated

Price:

100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521

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IRS4 Antibody (APC, Cy7) LS-C735816

Antibody:

IRS4 Rabbit anti-Mouse Polyclonal (APC, Cy7) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

APC, Cy7 Conjugated

Price:

100 µl/$513; 200 µl/$666; 500 µl/$1,175; 1 ml/$1,441; 2 ml/$2,017; 5 ml/$3,781

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IRS4 Antibody (PE) LS-C726892

Antibody:

IRS4 Rabbit anti-Mouse Polyclonal (PE) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

PE Conjugated

Price:

100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521

• Unconjugated
• HRP
• Biotin
• FITC
• Cy3
• APC
• APC, Cy7
• More...
  • PE

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • Cy3
  • APC
  • APC, Cy7
  • PE

Select

IRS4 Antibody LS-C663455

Antibody:

IRS4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225

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IRS4 Antibody (HRP) LS-C712830

Antibody:

IRS4 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$338; 200 µl/$393; 500 µl/$575; 1 ml/$702; 2 ml/$939; 5 ml/$1,593

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IRS4 Antibody (Biotin) LS-C688165

Antibody:

IRS4 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$596; 2 ml/$824; 5 ml/$1,348

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IRS4 Antibody (FITC) LS-C695085

Antibody:

IRS4 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$348; 200 µl/$407; 500 µl/$605; 1 ml/$755; 2 ml/$993; 5 ml/$1,716

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IRS4 Antibody (Cy3) LS-C703811

Antibody:

IRS4 Rabbit anti-Human Polyclonal (Cy3) Antibody

Reactivity:

Human

Applications:

WB

Format:

Cy3 Conjugated

Price:

100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451

Select

IRS4 Antibody (APC) LS-C741219

Antibody:

IRS4 Rabbit anti-Human Polyclonal (APC) Antibody

Reactivity:

Human

Applications:

WB

Format:

APC Conjugated

Price:

100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451

Select

IRS4 Antibody (APC, Cy7) LS-C735815

Antibody:

IRS4 Rabbit anti-Human Polyclonal (APC, Cy7) Antibody

Reactivity:

Human

Applications:

WB

Format:

APC, Cy7 Conjugated

Price:

100 µl/$505; 200 µl/$648; 500 µl/$1,152; 1 ml/$1,401; 2 ml/$1,961; 5 ml/$3,676

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IRS4 Antibody (PE) LS-C726894

Antibody:

IRS4 Rabbit anti-Human Polyclonal (PE) Antibody

Reactivity:

Human

Applications:

WB

Format:

PE Conjugated

Price:

100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451

• Unconjugated
• HRP
• Biotin
• FITC
• Cy3
• APC
• APC, Cy7
• More...
  • PE

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • Cy3
  • APC
  • APC, Cy7
  • PE

Select

IRS4 Antibody (aa875-925) LS-C762884

Antibody:

IRS4 Rabbit anti-Human Polyclonal (aa875-925) Antibody

Reactivity:

Human

Applications:

IP

Format:

Unconjugated

Price:

10 µg/$295; 100 µl/$514

Select

Pig IRS4 (Competitive EIA) ELISA Kit - LS-F38876

Type:

Competitive EIA

Format:

96-Well Strip Plate

Reactivity:

Pig

Range:

246.9 - 20000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$852

Select

Human IRS4 Protein (Recombinant GST, N-terminus) (aa850-950) - LS-G60734

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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