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Anti-IRF3 Antibody (aa108-166) LS-C45030

Catalog Size Price
LS-C45030-100 100 µg (1 mg/ml) Unavailable

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127 IRF3 Antibodies

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Anti-IRF3 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B182 concentration 5 ug/ml.
Anti-IRF3 Antibody (aa108-166) LS-C45030
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Anti-IRF3 Antibody IHC-plus™ LS-B2529
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Anti-IRF3 antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2529 dilution 1:50.
Anti-IRF3 Antibody (clone IRF35I218) LS-C184245
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Immunofluorescent staining using IRF3 antibody. Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were stained with anti-IRF3 antibody.
Anti-IRF3 Antibody (phospho-Ser396) LS-C380923
Rabbit Polyclonal (IgG) to Human IRF3
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Western blot, ELISA
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Anti-IRF3 Antibody (phospho-Ser396) antibody at 1:500 dilution with Jurkat cells treated with 200 ng/ml of EGF for 30 minutes.

100% Guaranteed
Mouse Monoclonal (IgG1) to Human IRF3
Human
Western blot, ELISA
Unconjugated

Details

Human IRF3
Mouse
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal
Unconjugated
Protein G purified
Unmodified

Applications

  • Western blot (1:2000 - 1:3000)
  • ELISA

Specificity and Use

IRF3 antibody was raised against recombinant human IRF3 (108-166aa) purified from E. coli.
aa108-166
Recognizes human interferon regulatory factor 3 (IRF3), a 55kD constitutively expressed member of the IRF family, which acts as vital regulator of gene expression in innate immunity. IRF3 accumulates in an inactive form in the cytoplasm and then translocates to the nucleus as a homodimer, following stimuli-induced phosphorylation of specific serine/threonine residues. Association of the homodimer with p300/CBP (CREBB binding protein) forms dsRNA-activated factor 1 (DRAF1), which then activates the transcription of interferon alpha and beta, along with other interferon-induced genes.
Western Blot: LS-C45030 detects a band of approximately 55kD in HeLa cell lysates.

Packaging

PBS, pH 7.4, 0.09% sodium azide.
4°C or -20°C, Avoid freeze-thaw cycles.
For research use only.

About IRF3

Q14653 NM_001571 NP_001562.1

IRF3 Antibody, Interferon regulatory factor 3 Antibody, IRF-3 Antibody

Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters.

Requested From: 
Date Requested: 5/20/2018

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