The Immunohistochemistry Antibody Company
|Human (tested or 100% immunogen sequence identity)|
|IRF3 antibody was raised against a synthetic peptide that maps to a region between residues 100 and 150 of human Interferon Regulatory Factor 3 using the numbering given in Swiss-Prot entry Q14653 (GeneID 3661).|
|Specific for human IRF3 protein. Other species not tested. Reactivity with mouse is possible owing to moderate conservation of sequence between this ortholog and human IRF3 at the site to which the epitope maps.|
|Suitable for use in Western Blot.|
|For research use only.|
IRF3 Antibody, Interferon regulatory factor 3 Antibody, IRF-3 AntibodyKey transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters.