The Immunohistochemistry Antibody Company
|Human, Mouse, Rat (tested or 100% immunogen sequence identity)|
|IRF2 antibody was raised against synthetic peptide (KLH-coupled) corresponding to residues surrounding Asp327 of human IRF-2.|
|Detects endogenous levels of total IRF-2 protein. Species sequence homology: Monkey.|
|Suitable for use in ELISA, Western Blot and Immunoprecipitation. Western Blot: 1:10-1:50. Immunoprecipitation: 1 ug/mg of total cell protein (~10^7 cells).|
|10 mM sodium HEPES, pH 7.5, 150 mM sodium chloride, 100 ug/ml BSA, 50% glycerol.|
|For research use only.|
IRF2 Antibody, IRF-2 Antibody, Interferon regulatory factor 2 AntibodySpecifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.