IRAK4 / IRAK-4

interleukin-1 receptor-associated kinase 4

Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections.

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Products

Antibodies (66)

Proteins (9)

ELISA Kits (2)

Type

Over-Expression Lysate (4)

Primary (66)

Recombinant (5)

Sandwich (2)

Target

IRAK4 / IRAK-4 (77)

Reactivity

Human (62)

Mouse (25)

Rat (7)

Bat (1)

Bovine (3)

Gibbon (3)

Horse (1)

Monkey (5)

Non-Human Primate (1)

Pig (3)

Sheep (3)

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Application

IHC (12)

IHC-Fr (1)

IHC-P (6)

WB (63)

Flo (3)

ELISA (23)

ICC (6)

IF (8)

Peptide-ELISA (2)

Host

rabbit (61)

mouse (4)

goat (1)

Product Group

IHCPlus (4)

Isotype

IgG (38)

IgG1 (3)

Clonality

monoclonal mc (4)

polyclonal pc (62)

Clone

2D3 (1)

2H9 (2)

Format

96-Well Strip Plate (2)

APC (1)

APC Conjugated (4)

Azide-free (2)

Biotin Conjugated (7)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (7)

HRP Conjugated (7)

PE Conjugated (5)

Unconjugated (34)

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Epitope

aa189-427 (8)

aa25-52 (7)

aa422-449 (7)

N-Terminus (5)

aa258-307 (4)

C-Terminus (2)

aa1-220 (2)

aa2-13 (1)

aa38-54 (1)

aa448-460 (1)

aa45-59 (1)

pSer346,pThr345 (1)

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Publications

No (76)

Yes (1)

Sample Type

Cell Lysates (1)

Tissue Homogenates (2)

Tag

GST (1)

GST, N-terminus (1)

His (2)

Myc-DDK (Flag) (5)

Species

Human (7)

Source

293T Cells (2)

Baculovirus (1)

E. coli (1)

HEK 293 Cells (3)

Wheat Germ Extract (2)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (1)

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IHC-plus™ IRAK4 / IRAK-4 Antibody LS-B1371

(4.0) Rating

Antibody:

IRAK4 / IRAK-4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.05 mg/$460

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IHC-plus™ IRAK4 / IRAK-4 Antibody (clone 2H9) LS-B10452

(4.0) Rating

Antibody:

IRAK4 / IRAK-4 Mouse anti-Human Monoclonal (2H9) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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IHC-plus™ IRAK4 / IRAK-4 Antibody (aa38-54) LS-B2048

(4.0) Rating

Antibody:

IRAK4 / IRAK-4 Rabbit anti-Mouse Polyclonal (aa38-54) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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IHC-plus™ IRAK4 / IRAK-4 Antibody (aa2-13) LS-B4823

(4.0) Rating

Antibody:

IRAK4 / IRAK-4 Goat anti-Human Polyclonal (aa2-13) Antibody

Reactivity:

Horse, Bat, Human, Monkey

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µg/$485

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IRAK4 / IRAK-4 Antibody (clone 2D3) LS-C133752

Antibody:

IRAK4 / IRAK-4 Mouse anti-Human Monoclonal (2D3) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$423

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IRAK4 / IRAK-4 Antibody LS-C334563

Antibody:

IRAK4 / IRAK-4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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Human IRAK4 / IRAK-4 (Sandwich ELISA) ELISA Kit - LS-F4782

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

1.56 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$798

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IRAK4 / IRAK-4 Antibody (aa422-449) LS-C164429

(4.0) Rating

(1) Publication(s)

Antibody:

IRAK4 / IRAK-4 Rabbit anti-Human Polyclonal (aa422-449) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

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IRAK4 / IRAK-4 Antibody LS-C812660

Antibody:

IRAK4 / IRAK-4 Mouse anti-Human Monoclonal Antibody

Reactivity:

Mouse, Human, Monkey

Applications:

ELISA, Flo, IHC, WB

Format:

Unconjugated

Price:

50 µg/$332; 100 µg/$404; 200 µg/$505

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Human IRAK4 / IRAK-4 Protein (Recombinant His) (aa189-427) - LS-G13949

Source:

E. coli

Tag:

His

Molecular Weight:

28.0 kDa

Price:

10 µg/$279; 50 µg/$425; 100 µg/$680; 200 µg/$850; 1 mg/$1,944; 500 µg/$1,490; 5 mg/$2,969; 2 mg/$2,131

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IRAK4 / IRAK-4 Antibody LS-C155351

Antibody:

IRAK4 / IRAK-4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$408

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IRAK4 / IRAK-4 Antibody (N-Terminus) LS-C8255

Antibody:

IRAK4 / IRAK-4 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Rat, Human

Applications:

IF, WB

Format:

Unconjugated

Price:

100 µg/$748

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IRAK4 / IRAK-4 Antibody (aa45-59) LS-C313078

Antibody:

IRAK4 / IRAK-4 Rabbit anti-Human Polyclonal (aa45-59) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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IRAK4 / IRAK-4 Antibody (clone 2H9) LS-C758956

Antibody:

IRAK4 / IRAK-4 Mouse anti-Human Monoclonal (2H9) Antibody

Reactivity:

Mouse, Human, Non-Human Primate

Applications:

Flo, IHC, WB

Format:

Unconjugated

Price:

100 µl/$541

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IRAK4 / IRAK-4 Antibody (aa189-427, APC, Cy7) LS-C732886

Antibody:

IRAK4 / IRAK-4 Rabbit anti-Human Polyclonal (aa189-427) (APC, Cy7) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

APC, Cy7 Conjugated

Price:

100 µl/$489; 200 µl/$614; 500 µl/$1,108; 1 ml/$1,329; 2 ml/$1,860; 5 ml/$3,487

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IRAK4 / IRAK-4 Antibody (C-Terminus) LS-C83586

Antibody:

IRAK4 / IRAK-4 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

ICC, IF, WB

Format:

Unconjugated

Price:

100 µg/$522

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IRAK4 / IRAK-4 Antibody (phospho-Ser346,pThr345) LS-C806741

Antibody:

IRAK4 / IRAK-4 Rabbit anti-Human Polyclonal (pSer346,pThr345) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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IRAK4 / IRAK-4 Antibody (aa422-449) LS-C329691

Antibody:

IRAK4 / IRAK-4 Rabbit anti-Mouse Polyclonal (aa422-449) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

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IRAK4 / IRAK-4 Antibody LS-C341969

Antibody:

IRAK4 / IRAK-4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

50 µl/$356; 100 µl/$461

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IRAK4 / IRAK-4 Antibody (aa1-220) LS-C375972

Antibody:

IRAK4 / IRAK-4 Rabbit anti-Human Polyclonal (aa1-220) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

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IRAK4 / IRAK-4 Antibody LS-C400833

Antibody:

IRAK4 / IRAK-4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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IRAK4 / IRAK-4 Antibody (aa448-460) LS-C8253

Antibody:

IRAK4 / IRAK-4 Rabbit anti-Human Polyclonal (aa448-460) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$649

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IRAK4 / IRAK-4 Antibody (aa25-52) LS-C329693

Antibody:

IRAK4 / IRAK-4 Rabbit anti-Human Polyclonal (aa25-52) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

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IRAK4 / IRAK-4 Antibody (aa25-52, Biotin) LS-C260345

Antibody:

IRAK4 / IRAK-4 Rabbit anti-Human Polyclonal (aa25-52) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin

• Unconjugated
• Biotin

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IRAK4 / IRAK-4 Antibody LS-C666483

Antibody:

IRAK4 / IRAK-4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$331

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