Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
(tested or 100% immunogen sequence identity)
Monkey, Horse (at least 90% immunogen sequence identity)
Western blot (1 - 2 µg/ml)
IRAK4 / IRAK-4 antibody was raised against synthetic peptide corresponding to amino acids at C-terminus of human IRAK-4 (C-KKVQQLLQEMTAS) (4). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Marmoset, Porcine (100%); Monkey, Horse (92%); Elephant, Bat, Bovine, Rabbit (85%).
Detects IRAK 4 (IL-1R-associated Kinase). Does not cross-react to other IRAKs.
Suitable for use in ELISA, Western Blot. Western Blot: 1-2 ug/ml. detects a 50kD band. Positive control: HeLa cell lysate.
PBS, pH 7.2, 0.02% Sodium Azide
Short term: 4°C; Long term: Add glycerol (40-50%) -20°C.
Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1.