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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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IRAK4 / IRAK‑4 Antibody (aa448‑460) LS‑C8253
Antibody
IRAK-4 antibody LS-C8253 is an unconjugated rabbit polyclonal antibody to human IRAK-4 (IRAK4). Validated for ELISA and WB.
Catalog
Size
Price
LS-C8253-100
100 µg
Unavailable

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Antibody
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Product Description

IRAK-4 antibody LS-C8253 is an unconjugated rabbit polyclonal antibody to human IRAK-4 (IRAK4). Validated for ELISA and WB.
About IRAK4 / IRAK-4
Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Q9NWZ3 NM_016123 NP_057207.2

IRAK4 Antibody, IPD1 Antibody, IRAK-4 Antibody, NY-REN-64 Antibody, REN64 Antibody


Specifications

Target
Human IRAK4 / IRAK-4
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Predicted
Monkey, Horse (at least 90% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • Western blot (1 - 2 µg/ml)
  • ELISA
Immunogen
IRAK4 / IRAK-4 antibody was raised against synthetic peptide corresponding to amino acids at C-terminus of human IRAK-4 (C-KKVQQLLQEMTAS) (4). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Marmoset, Porcine (100%); Monkey, Horse (92%); Elephant, Bat, Bovine, Rabbit (85%).
Epitope
aa448-460
Specificity
Detects IRAK 4 (IL-1R-associated Kinase). Does not cross-react to other IRAKs.
Usage
Suitable for use in ELISA, Western Blot. Western Blot: 1-2 ug/ml. detects a 50kD band. Positive control: HeLa cell lysate.
Presentation
PBS, pH 7.2, 0.02% sodium azide.
Storage
Short term: 4°C; Long term: Add glycerol (40-50%) -20°C.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

Publications (0)


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Requested From: 
Date Requested: 6/25/2018

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