IRAK1 / IRAK

interleukin-1 receptor-associated kinase 1

Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3.

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Products

Antibodies (78)

Proteins (12)

ELISA Kits (7)

Type

Cell-Based Phosphorylation (2)

Custom (1)

Over-Expression Lysate (7)

Primary (78)

Recombinant (5)

Sandwich (4)

Target

IRAK1 / IRAK (97)

Reactivity

Human (76)

Mouse (33)

Rat (19)

Monkey (1)

Application

IHC (19)

IHC-Fr (1)

IHC-P (9)

WB (70)

Flo (7)

ELISA (30)

ICC (5)

IF (11)

IP (13)

Peptide-ELISA (7)

RNAi (1)

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Host

rabbit (68)

mouse (9)

goat (1)

Product Group

IHCPlus (4)

Isotype

Ig (1)

IgG (53)

IgG1 (1)

IgG1,k (1)

IgG2a (4)

IgG2a,k (2)

Clonality

monoclonal mc (8)

polyclonal pc (70)

Clone

3A9 (1)

3F7 (1)

8F1A7 (1)

Format

96-Well Microplate (2)

96-Well Strip Plate (5)

APC (1)

APC Conjugated (4)

Azide-free (2)

Biotin Conjugated (5)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (5)

HRP Conjugated (5)

PE Conjugated (5)

Unconjugated (52)

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Epitope

aa212-440 (8)

aa405-433 (7)

aa530-693 (5)

pThr209 (4)

pSer376 (3)

C-Terminus (2)

pThr100 (2)

pThr387 (2)

150-230 aa (1)

320-400 aa (1)

330-410 aa (1)

40-120 aa (1)

Ab-376 (1)

Ile205 (1)

Thr381 (1)

aa175-224 (1)

aa18-37 (1)

aa342-391 (1)

aa353-402 (1)

aa575-625 (1)

aa662-712 (1)

aa683-712 (1)

aa700-712 (1)

p209 (1)

p387 (1)

pT387 (1)

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Publications

No (96)

Yes (1)

Sample Type

Adherent Cell Cultures (2)

Cell Culture Supernatants (1)

Cell Lysates (1)

Plasma (3)

Serum (3)

Tissue Homogenates (3)

Tag

GST (1)

GST, N-terminus (1)

GST, N-terminus + His, C-terminus (1)

His (1)

Myc-DDK (Flag) (8)

Species

Human (9)

Source

293T Cells (4)

E. coli (2)

HEK 293 Cells (4)

Wheat Germ Extract (2)

Purification

Purified (1)

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IHC-plus™ IRAK1 / IRAK Antibody (clone 3F7) LS-B4360

(4.0) Rating

Antibody:

IRAK1 / IRAK Mouse anti-Human Monoclonal (3F7) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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IRAK1 / IRAK Antibody (aa530-693, Biotin) LS-C225689

Antibody:

IRAK1 / IRAK Mouse anti-Human Monoclonal (aa530-693) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

Biotin Conjugated

Price:

100 µl/$904

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IRAK1 / IRAK Antibody (aa405-433) LS-C164426

Antibody:

IRAK1 / IRAK Rabbit anti-Mouse Polyclonal (aa405-433) Antibody

Reactivity:

Mouse

Applications:

Flo, WB

Format:

Unconjugated

Price:

400 µl/$393

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IRAK1 / IRAK Antibody (phospho-Thr209) LS-C352383

Antibody:

IRAK1 / IRAK Rabbit anti-Human Polyclonal (pThr209) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$315

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IHC-plus™ IRAK1 / IRAK Antibody (clone 3A9) LS-B4361

(4.0) Rating

Antibody:

IRAK1 / IRAK Mouse anti-Human Monoclonal (3A9) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P, IP, RNAi, WB

Format:

Unconjugated

Price:

50 µg/$440

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Human IRAK1 / IRAK (Sandwich ELISA) ELISA Kit - LS-F11834

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Mouse IRAK1 / IRAK (Sandwich ELISA) ELISA Kit - LS-F17880

(4.0) Rating

(1) Publication(s)

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$783

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Human Phospho-IRAK1 / IRAK (Thr209) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1401

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$772

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Human IRAK1 / IRAK (Sandwich ELISA) ELISA Kit - LS-F4780

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$798

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IRAK1 / IRAK Antibody LS-C249

Antibody:

IRAK1 / IRAK Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, ICC, IF, IP, WB

Format:

Unconjugated

Price:

0.1 mg/$448

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IRAK1 / IRAK Antibody (phospho-Ser376) LS-C757844

Antibody:

IRAK1 / IRAK Rabbit anti-Human Polyclonal (pSer376) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC-P, WB

Format:

Unconjugated

Price:

200 µl/$393

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IRAK1 / IRAK Antibody (aa18-37) LS-C313289

Antibody:

IRAK1 / IRAK Rabbit anti-Human Polyclonal (aa18-37) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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IHC-plus™ IRAK1 / IRAK Antibody (aa175-224) LS-B7660

(4.0) Rating

Antibody:

IRAK1 / IRAK Rabbit anti-Human Polyclonal (aa175-224) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$460

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IRAK1 / IRAK Antibody (clone 8F1A7) LS-C144494

Antibody:

IRAK1 / IRAK Mouse anti-Human Monoclonal (8F1A7) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

0.1 mg/$502

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IRAK1 / IRAK Antibody (40-120 aa) LS-C381356

Antibody:

IRAK1 / IRAK Rabbit anti-Human Polyclonal (40-120 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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IRAK1 / IRAK Antibody (330-410 aa) LS-C384180

Antibody:

IRAK1 / IRAK Rabbit anti-Human Polyclonal (330-410 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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IRAK1 / IRAK Antibody (aa405-433, Biotin) LS-C222919

Antibody:

IRAK1 / IRAK Rabbit anti-Mouse Polyclonal (aa405-433) (Biotin) Antibody

Reactivity:

Mouse

Applications:

ELISA, Flo, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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IRAK1 / IRAK Antibody (phospho-T387) LS-C381758

Antibody:

IRAK1 / IRAK Rabbit anti-Human Polyclonal (pT387) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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IRAK1 / IRAK Antibody (150-230 aa) LS-C380974

Antibody:

IRAK1 / IRAK Rabbit anti-Human Polyclonal (150-230 aa) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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IRAK1 / IRAK Antibody (aa353-402) LS-C117657

Antibody:

IRAK1 / IRAK Rabbit anti-Human Polyclonal (aa353-402) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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IRAK1 / IRAK Antibody (phospho-Thr209) LS-C199134

Antibody:

IRAK1 / IRAK Rabbit anti-Human Polyclonal (pThr209) Antibody

Reactivity:

Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

IRAK1 / IRAK Antibody (Biotin) LS-C527297

Antibody:

IRAK1 / IRAK Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Biotin Conjugated

Price:

100 µl/$1,006

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IRAK1 / IRAK Antibody (Biotin) LS-C522625

Antibody:

IRAK1 / IRAK Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$937

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IRAK1 / IRAK Antibody (aa212-440, Biotin) LS-C685994

Antibody:

IRAK1 / IRAK Rabbit anti-Human Polyclonal (aa212-440) (Biotin) Antibody

Reactivity:

Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$313; 200 µl/$357; 500 µl/$503; 1 ml/$576; 2 ml/$788; 5 ml/$1,279

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IHC-plus™ IRAK1 / IRAK Antibody (aa683-712) LS-B3462

(4.0) Rating

Antibody:

IRAK1 / IRAK Rabbit anti-Human Polyclonal (aa683-712) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

200 µl/$460

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