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IQSEC2
IQ Motif And Sec7 Domain 2
IQSEC2 encodes a guanine nucleotide exchange factor for the ARF family of small GTP-binding proteins. The encoded protein is a component of the postsynaptic density at excitatory synapses, and may play a critical role in cytoskeletal and synaptic organization through the activation of selected ARF substrates including ARF1 and ARF6. Mutations in this gene have been implicated in nonsyndromic X-linked mental retardation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
| Gene Name: | IQ Motif And Sec7 Domain 2 |
| Synonyms: | IQSEC2, BRAG1, IQ motif and Sec7 domain 2, MRX1, KIAA0522 |
| Target Sequences: | AB011094 BAA25448.1 Q5JU85 |
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