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In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin.
Gene Name: | IQ Motif And Sec7 Domain 1 |
Synonyms: | IQSEC1, ARF-GEP100, ARFGEP100, Brefeldin A-resistant ARF-GEF2, BRAG2, IQ motif and Sec7 domain 1, KIAA0763, GEP100 |
Target Sequences: | NM_014869 NP_055684.3 Q6DN90 |
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