Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
IPO7 Antibody, Importin-7 Antibody, Importin 7 Antibody, Ran-binding protein 7 Antibody, Imp7 Antibody, RAN binding protein 7 Antibody, RanBP7 Antibody
Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism.
IHC of IOP7 in formalin-fixed, paraffin-embedded mouse spleen tissue using an isotype control (top) and LS-C148725 (bottom) at 5 ug/ml.
Western blot ofIOP7 inMCF7 cell lysate in the 1) absence and2) presence of immunizing peptide, and 3) RAW cell lysate using LS-C148725 at 1 ug/ml. Goat anti-rabbit Ig HRP secondary antibody, and PicoTect ECL substrate solution were used for this test.