Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human (tested or 100% immunogen sequence identity)
Monkey, Horse (at least 90% immunogen sequence identity)
Western blot (1:500 - 1:1000)
Specificity and Use
IPAF / NLRC4 antibody was raised against n terminus (MNFIKDNSRALIQRMGM) of the A and B isoforms of the human CLAN protein. Percent identity by BLAST analysis: Human (100%); Gorilla, Gibbon, Monkey, Horse (94%); Bat (82%).
Reacts with the N terminus (MNFIKDNSRALIQRMGM) of the A and B isoforms of the human CLAN protein.
PBS, 0.02% sodium azide.
Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adaptor molecules and proteases including several members of the caspase family. Another family of proteins that functions as a critical regulator of apoptosis and NF-kB signaling pathways is the CED-4/Apaf-1 (apoptosis protein activating factor-1) protein family.