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IPAF / NLRC4
NLR family, CARD domain containing 4
Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adaptor molecules and proteases including several members of the caspase family. Another family of proteins that functions as a critical regulator of apoptosis and NF-kB signaling pathways is the CED-4/Apaf-1 (apoptosis protein activating factor-1) protein family. Ipaf (ICE protease activating factor) is a CED-4/Apaf-1 family member that activates caspase-1/ICE and can induce apoptosis in human cells in a caspase-1 dependent manner. Ipaf and caspase-1 are thought to interact with each other through the association of the Ipaf amino-terminal CARD (caspase recruitment domain) and amino-terminal CARD of caspase-1.
| Gene Name: | NLR family, CARD domain containing 4 |
| Family/Subfamily: | Apoptosis |
| Synonyms: | NLRC4, CARD12, CLANA, CLANB, CLANC, CLAND, CLAN, CLR2.1, Clan protein, CLAN1, Ice protease-activating factor, NOD-like receptor C4, ICE-protease activating factor, IPAF |
| Target Sequences: | NM_021209 NP_067032.3 Q9NPP4 |
Publications (3)
1
HUWE1 mediates inflammasome activation and promotes host defense against bacterial infection. Yu Guo, Longjun Li, Tao Xu, Xiaomin Guo, Chaoming Wang, Yihui Li, Yanan Yang, Dong Yang, Bin Sun, Xudong Zhao, Genze Shao, Xiaopeng Qi. The Journal of clinical investigation. 2020 December;130:6301-6316. [Full Text Article]
[PubMed:33104527]
[PMC:PMC7685759]
Related Antibodies: LS-C148271.
2
Suppression of Inflammasome Activation by IRF8 and IRF4 in cDCs Is Critical for T Cell Priming. Margaret M McDaniel, Leah C Kottyan, Harinder Singh, Chandrashekhar Pasare. Cell reports. 2020 May;31:107604. [Full Text Article]
[PubMed:32375053]
[PMC:PMC7325595]
Related Antibodies: LS-C407885.
3
Staphylococcus aureus a-Toxin Induces Inflammatory Cytokines via Lysosomal Acid Sphingomyelinase and Ceramides. Jie Ma, Erich Gulbins, Michael J Edwards, Charles C Caldwell, Martin Fraunholz, Katrin Anne Becker. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2017 43:2170-2184. [Full Text Article]
[PubMed:29069651]
Related Antibodies: LS-C148271.
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IPAF / NLRC4 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$545
IPAF / NLRC4 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50 µl/$386
IPAF / NLRC4 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ICC, IF, IHC, IHC-P
Unconjugated
0.1 ml/$386
IPAF / NLRC4 Rabbit anti-Human Polyclonal (Biotin) Antibody
Mouse, Human
ICC, IF, IHC, IHC-P
Biotin Conjugated
0.1 ml/$416
IPAF / NLRC4 Rabbit anti-Human Polyclonal (DY650) Antibody
Mouse, Human
ICC, IF, IHC, IHC-P
DY650 Conjugated
0.1 ml/$416
IPAF / NLRC4 Rabbit anti-Human Polyclonal (DY488) Antibody
Mouse, Human
ICC, IF, IHC, IHC-P
DY488 Conjugated
0.1 ml/$416
IPAF / NLRC4 Rabbit anti-Human Polyclonal (DY550) Antibody
Mouse, Human
ICC, IF, IHC, IHC-P
DY550 Conjugated
0.1 ml/$416
IPAF / NLRC4 Rabbit anti-Human Polyclonal (aa838-874) Antibody
Mouse, Rat, Human
WB
Unconjugated
10 µg/$318; 100 µg/$470
IPAF / NLRC4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IF, IHC-P, WB
Unconjugated
50 µl/$460
IPAF / NLRC4 Rabbit anti-Human Polyclonal (aa941-990) Antibody
Human
IHC, WB
Unconjugated
100 µl/$424
IPAF / NLRC4 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, IP, WB
Unconjugated
50 µl/$572
IPAF / NLRC4 Mouse anti-Mouse Monoclonal (aa525-538, pSer533) (9A6A1) Antibody
Mouse
ELISA, Flo, ICC, IHC
Unconjugated
100 µl/$459
IPAF / NLRC4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
IPAF / NLRC4 Mouse anti-Mouse Monoclonal (aa525-538, pSer533) (4B7B7) Antibody
Mouse
ELISA, ICC, IHC, WB
Unconjugated
100 µl/$459
IPAF / NLRC4 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
50 µg/$444; 100 µg/$597
IPAF / NLRC4 Rabbit anti-Human Polyclonal (aa116-145) Antibody
Human
WB
Unconjugated
400 µl/$393
IPAF / NLRC4 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ICC, IF, IHC, IHC-P
Unconjugated
0.1 ml/$386
IPAF / NLRC4 Rabbit anti-Human Polyclonal (Biotin) Antibody
Mouse, Human
ICC, IF, IHC, IHC-P
Biotin Conjugated
0.1 ml/$416
IPAF / NLRC4 Rabbit anti-Human Polyclonal (DY650) Antibody
Mouse, Human
ICC, IF, IHC, IHC-P
DY650 Conjugated
0.1 ml/$416
IPAF / NLRC4 Rabbit anti-Human Polyclonal (DY488) Antibody
Mouse, Human
ICC, IF, IHC, IHC-P
DY488 Conjugated
0.1 ml/$416
IPAF / NLRC4 Rabbit anti-Human Polyclonal (DY550) Antibody
Mouse, Human
ICC, IF, IHC, IHC-P
DY550 Conjugated
0.1 ml/$416
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
IPAF / NLRC4 Rabbit anti-Human Polyclonal (aa1-250) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
IPAF / NLRC4 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IP, WB
Unconjugated
50 µl/$393
IPAF / NLRC4 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, IP, WB
Unconjugated
50 µl/$393
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