Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 05] (IgG2b) to Human Integrin Alpha5 Beta1
Rat Monoclonal (IgG3) to Mouse Integrin Alpha5 Beta1
Western blot, Immunoprecipitation, Flow Cytometry, Functional Assay
Mouse Integrin Alpha5 Beta1
Mouse (tested or 100% immunogen sequence identity)
Specificity and Use
Mouse embryonal carcinoma P19 cells with myeloma P3X63Ag9.653 cells.
Recognizes mouse integrin VLA-5 (a5b1), a fibronectin receptor. Species cross-reactivity: Mouse.
Inhibition of cell adhesion to fibronectin: 10 mg/ml Note that where cell adhesion to fibronectin involving other fibronectin receptors, such as VLA-4 (a4b1) integrin, is involved, inhibition of cell adhesion by BMB5 alone may not be complete. Immunoprecipitation from lysate of 1E6 cell equivalent: 2mg. Flow cytometry: 10 mg/ml Western blot (non-reducing gel).