Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Rat Monoclonal [clone DATK32 (DATK-32)] (IgG2a,k) to Mouse Integrin Alpha4 Beta7 / LPAM-1
Mouse Integrin Alpha4 Beta7 / LPAM-1
Mouse (tested or 100% immunogen sequence identity)
IgG2a,k Monoclonal [DATK32 (DATK-32)]
Specificity and Use
Mouse Integrin Alpha4 Beta7 (ITGA4/ITGB7)
This DATK32 (DATK-32) antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.5 ug per test. A test is defined as the amount (ug) of antibody that will stain a cell sample in a final volume of 100 ul. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
PBS, pH 7.2, <=0.09% sodium azide
Store at +4°C. Do not freeze. Product is photosensitive and should be protected from light.
For research use only.
About Integrin Alpha4 Beta7 / LPAM-1
LPAM-1 (integrin alpha 4 beta 7) mediates lymphocyte attachment within the extracellular matrix (ECM) by adhering to the connecting segment (CS)-1 site of fibronectin (FN). It is upregulated in atherosclerotic lesions and is involved in atherosclerosis progression.
Staining of C57Bl/6 bone marrow cells with FITC anti-mo/hu B220 (RA3-6B2) (LS-C105879) and 0.125 ug of APC Rat IgG2a isotype control (left) or 0.125 ug of APC anti-mouse LPAM-1 (DATK32) (right). Total viable cells were used for analysis.
Requested From: United States
Date Requested: 10/24/2016