Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone CII-11] (IgG1) to Rat Insulin C-Peptide
Rat Insulin C-Peptide
Rat, Mouse (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [CII-11]
Specificity and Use
Fragments of rat C-peptide conjugated to a carrier protein.
Recognizes rat C-peptide. C-peptide is a 31 amino acid peptide released when proinsulin is split into insulin and C-peptide. In rats, two isoforms of proinsulin exists, the difference is two amino acid residues in the C-peptide, termed C-peptide I and C-peptide II. Proinsulin is split when it is released from the pancreas into the blood in response to a rise in serum glucose levels. C-peptide function is not fully understood, it binds to cell membranes which leads to increased intracellular Ca2+ concentration and subsequent stimulation of N+, K+-ATPase and endothelial nitric oxide synthase activities. C-peptide also functions in repair of the muscular layer of arteries. Recognizes an epitope in the N-terminal region of rat and mouse C-peptide I and II with almost equal affinity. Reacts very weakly with rat proinsulin. May be used to detect rat or mouse C-peptide I or II in ELISA assays.
ELISA: This product may be used in an indirect ELISA or as a detection antibody in a sandwich ELISA to detect rat C-peptide I or II together with LS-C58409 as capture reagent. This sandwich ELISA configuration is only suitable for the detection of rat and not mouse C-peptide I or II.