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Anti-Insulin Antibody LS-C187656

Ordering

Wt. Vol. Conc. Price
- 50 µl 5 mg/ml $325
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular Insulin Antibodies

Anti-Insulin Antibody (clone 8E2, HRP) IHC-plus™ LS-B2407
Mouse Monoclonal [clone 8E2] (IgG1,k) to Human Insulin
Human
IHC - Paraffin, ELISA
HRP Conjugated
Immunohistochemistry Image
Anti-Insulin Antibody IHC-plus™ LS-B2526
Rabbit Polyclonal (IgG) to Human Insulin
Human, Mouse, Rat
IHC - Paraffin, ICC, Immunofluorescence, Flow Cytometry
Unconjugated
Immunohistochemistry Image
Anti-Insulin Antibody LS-C190934
Guinea pig Polyclonal (IgG) to Human Insulin
Human, Bovine, Pig
ELISA
Unconjugated

100% Guaranteed 100% Guaranteed
Guinea pig Polyclonal (IgG) to Pig Insulin
Pig, Mouse
IHC - Frozen, ELISA
Unconjugated

Details

Pig Insulin
Guinea pig
Pig, Mouse (tested or 100% immunogen sequence identity)
IgG Polyclonal
Unconjugated
Purified
Unmodified

Applications

  • IHC - Frozen (1:50 - 1:1600)
  • ELISA

Specificity and Use

Insulin antibody was raised against native.
Guinearecognizes porcine insulin, a hormone secreted by the beta cells of the islets of Langerhans in the pancreas. Insulin belongs to a family of hormones including the insulin-like growth hormones and the relaxins. The insulin precursor is a 108amino acid polypeptide consisting of a 24 aa signal peptide, an insulin A chain, a prohormone polypeptide and an insulin B chain together having a predicted molecular mass of 11672 Da. Active insulin migrates with an apparent molecular mass of 6kD in western blotting of porcine, bovine and lapine samples. Insulin is a hormone that functions in carbohydrate homeostasis, and acts to decrease blood glucose concentration by increasing cell permeability to monosaccharides, amino acids and fatty acids, and accelerate glycolysis and glycogen synthesis in the liver, it induces uptake of glucose into cells through its interaction with the glucose transporter GLUT4. Deficiency of insulin results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of B-cell origin such as insulinoma. Guineahas been successfully used to demonstrate the presence of insulin in the islets of Langerhans of murine pancreas using immunohistochemistry on paraffin embedded material.

Packaging

PBS, 0.09% sodium azide
+4°C or -20°C, Avoid repeated freezing and thawing.
For research use only.

About Insulin

P01308 NM_000207 NP_000198.1

INS Antibody, IRDN Antibody, IDDM2 Antibody, Preproinsulin Antibody, ILPR Antibody, Insulin Antibody, MODY10 Antibody, Proinsulin Antibody

After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified.

Requested From: United States
Date Requested: 12/8/2016

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