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Anti-Insulin Antibody (clone IN-05, Azide-free) LS-C45707

Catalog Size Price
LS-C45707-100 100 µg Unavailable

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100% Guaranteed
Mouse Monoclonal [clone IN-05] (IgG1) to Pig Insulin
Pig, Human, Bovine
IHC - Paraffin, ICC, ELISA, Blocking, Functional Assay, Neutralization, Radioimmunoassay
Unconjugated, Azide-free

Details

Pig Insulin
Mouse
Pig, Human, Bovine (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [IN-05]
Unconjugated
Protein A purified
Azide-free

Applications

  • IHC - Paraffin
  • ICC
  • ELISA
  • Blocking
  • Functional Assay
  • Neutralization
  • Radioimmunoassay

Specificity and Use

Insulin antibody was raised against porcine insulin.
Reacts with insulin, one of the major regulatory endocrine hormones of intermediate metabolism, normally secreted by the beta cells (a type of islet cells) of the pancreas; it is also present in tumors of B cell origin such as insulinoma
Functional Application: The antibody IN-05 blocks binding of insulin to the receptor. The applications listed have been tested for the unmodified form of this product. Other forms have not been tested.

Packaging

Azide free PBS, preserved by filter sterilization, approx., pH 7.4.
Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
For research use only.

About Insulin

P01308 NM_000207 NP_000198.1

INS Antibody, IRDN Antibody, IDDM2 Antibody, Preproinsulin Antibody, ILPR Antibody, Insulin Antibody, MODY10 Antibody, Proinsulin Antibody

After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified.

Requested From: 
Date Requested: 8/18/2017

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