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Anti-INSR / Insulin Receptor Antibody (aa1368-1382) LS-C36915

Ordering

Wt. Vol. Conc. Price
50 µg - 0.1 mg/ml $385
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular INSR / Insulin Receptor Antibodies

Anti-INSR / Insulin Receptor Antibody (phospho-Tyr1361) LS-C177981
Rabbit Polyclonal to Human INSR / Insulin Receptor
Human, Mouse, Rat
Western blot
Unconjugated
Western blot Image
Anti-INSR / Insulin Receptor Antibody (Internal) IHC-plus™ LS-A9422
Rabbit Polyclonal to Human INSR / Insulin Receptor
Human, Monkey
IHC - Paraffin
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Mouse Monoclonal (IgG1,k) to Human INSR / Insulin Receptor
Human
Immunoprecipitation, ELISA, Functional Assay
Unconjugated

Details

Human INSR / Insulin Receptor
Mouse
Human (tested or 100% immunogen sequence identity)
Monkey, Bovine, Dog, Horse, Pig (at least 90% immunogen sequence identity)
IgG1,k Monoclonal
Unconjugated
Protein G purified
Unmodified

Applications

  • Immunoprecipitation
  • ELISA
  • Functional Assay

Specificity and Use

INSR / Insulin Receptor antibody was raised against a synthetic peptide corresponding to amino acid residues YKKNGRILTLPRSNPS from the C-terminal region of human insulin receptor b-subunit. Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Panda, Dog, Bovine, Horse, Pig (94%); Marmoset, Mouse, Rat, Hamster, Elephant, Opossum (88%); Bat, Trout, Stickleback, Pufferfish, Zebrafish (81%).
aa1368-1382
Recognizes a protein with Mr95kD, identified as the b-subunit of insulin receptor (IR). Recognizes an epitope aa-GRVLTLPRS-within the C-terminus. Shows no cross-reactivity with insulin-like growth factor (IGF)-receptors. Recognizes autophosphorylated IR, unoccupied IR and the insulin-IR complex. Has no effect on insulin-stimulated autophosphorylation. Species cross-reactivity: Human, mouse and rat.
Suitable for use in ELISA, Immunoprecipitation and Tyrosine Kinase Assay. Immunoprecipitation: Mouse IR. Tyrosine Kinase Assay: Preparations from which the BSA have been omitted have been used successfully in immunoaffinity chromatography (with peptide elution) and in ELISA as a capture antibody. Positive control: IM-9 lymphocytes.

Packaging

PBS, pH 7.4, 0.2% BSA, 0.09% sodium azide, 40% glycerol.
For research use only.

About INSR / Insulin Receptor

P06213 NM_000208 NP_000199.2

INSR Antibody, CD220 Antibody, ILP receptor Antibody, Insulin receptor Antibody, IR Antibody, HHF5 Antibody, CD220 antigen Antibody

Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates.

Requested From: United States
Date Requested: 12/6/2016

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