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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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INSIG1 Antibody (Internal) LS‑C70714
Antibody
INSIG1 antibody LS-C70714 is an unconjugated rabbit polyclonal antibody to human INSIG1. Validated for WB.
Catalog
Size
Price
LS-C70714-100
100 µl
Unavailable

Popular INSIG1 Products

Anti-INSIG1 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2420 concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human
Applications: IHC, IHC - Paraffin, Western blot
Anti-INSIG1 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2420 concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human, Rat
Applications: IHC, IHC - Paraffin, Western blot
Anti-INSIG1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6815 concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Goat, Guinea pig, Hamster, Horse, Pig, Rabbit, Chicken, Xenopus
Applications: IHC, IHC - Paraffin, Western blot
INSIG1 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human prostate carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.
Species: Human
Applications: IHC, IHC - Paraffin, Western blot, Flow Cytometry
Antibody
Species: Human
Applications: IHC, Immunofluorescence, Western blot, Immunoprecipitation, ELISA

Product Description

INSIG1 antibody LS-C70714 is an unconjugated rabbit polyclonal antibody to human INSIG1. Validated for WB.
About INSIG1
Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. O15503 NM_005542 NP_005533.2

INSIG1 Antibody, Cl-6 Antibody, CL6 Antibody, INSIG-1 Antibody, Insulin induced gene 1 Antibody, Insulin-induced gene 1 protein Antibody, INSIG-1 membrane protein Antibody


Specifications

Target
Human INSIG1
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • Western blot
Immunogen
INSIG1 antibody was raised against a synthetic peptide representing an internal region of the human protein (between residues 1-100) according to Swiss-Prot# O15503. Homology: 100% with human protein. No other significant species homology.
Epitope
Internal
Specificity
This antibody is specific for Insig1 but not Insig2. Species cross-reactivity: This antibody reacts with human protein. Other species have not been tested.
Usage
Suitable for use in Western Blot. Positive control: HepG2 lysate.
Presentation
PBS + 30% glycerol.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: 
Date Requested: 6/22/2018

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