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INA / Alpha Internexin

internexin neuronal intermediate filament protein, alpha

Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NF-L to form the filamentous backbone to which NF-M and NF-H attach to form the cross-bridges.

Gene Name:	internexin neuronal intermediate filament protein, alpha
Synonyms:	INA, 66 kDa neurofilament protein, Alpha Internexin, Alpha-internexin, Alpha-Inx, NEF5, Neurofilament 5, Neurofilament-66, NF-66, TXBP-1, Neurofilament 5 (66kD)
Target Sequences:	NM_032727 NP_116116.1 Q16352

Publications (27)

Characterization of mitotic neurons derived from adult rat hypothalamus and brain stem. Evans J, Sumners C, Moore J, Huentelman MJ, Deng J, Gelband CH, Shaw G. Journal of neurophysiology. 2002 87:1076-85. [PubMed:11826071]

Preferential transformation of human neuronal cells by human adenoviruses and the origin of HEK 293 cells. Shaw G, Morse S, Ararat M, Graham FL. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2002 16:869-71. [PubMed:11967234]

Reduced number of unmyelinated sensory axons in peripherin null mice. Larivire RC, Nguyen MD, Ribeiro-da-Silva A, Julien JP. Journal of neurochemistry. 2002 81:525-32. [PubMed:12065660]

Axonally transported peripheral signals regulate alpha-internexin expression in regenerating motoneurons. McGraw TS, Mickle JP, Shaw G, Streit WJ. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2002 22:4955-63. [PubMed:12077192]

Spontaneous differentiation of porcine and bovine embryonic stem cells (epiblast) into astrocytes or neurons. Talbot NC, Powell AM, Garrett WM. In vitro cellular & developmental biology. Animal. 2002 38:191-7. [PubMed:12197769]

cAMP-induced differentiation of human neuronal progenitor cells is mediated by nuclear fibroblast growth factor receptor-1 (FGFR1). Stachowiak EK, Fang X, Myers J, Dunham S, Stachowiak MK. Journal of neurochemistry. 2003 84:1296-312. [PubMed:12614330]

Peripheral medulloepithelioma: an immunohistochemical, ultrastructural, and cytogenetic study of a rare, chemotherapy-sensitive, pediatric tumor. Donner LR, Teshima I. The American journal of surgical pathology. 2003 27:1008-12. [PubMed:12826895]

Substrates and routes of migration of early generated neurons in the developing rat thalamus. Ortino B, Inverardi F, Morante-Oria J, Fairn A, Frassoni C. The European journal of neuroscience. 2003 18:323-32. [PubMed:12887414]

Neurofilament transport in vivo minimally requires hetero-oligomer formation. Yuan A, Rao MV, Kumar A, Julien JP, Nixon RA. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2003 23:9452-8. [PubMed:14561875]

alpha-internexin is present in the pathological inclusions of neuronal intermediate filament inclusion disease. Cairns NJ, Zhukareva V, Uryu K, Zhang B, Bigio E, Mackenzie IR, Gearing M, Duyckaerts C, Yokoo H, Nakazato Y, Jaros E, Perry RH, Lee VM, Trojanowski JQ. The American journal of pathology. 2004 164:2153-61. [PubMed:15161649] [PMC:PMC1615782]

alpha-Internexin aggregates are abundant in neuronal intermediate filament inclusion disease (NIFID) but rare in other neurodegenerative diseases. Cairns NJ, Uryu K, Bigio EH, Mackenzie IR, Gearing M, Duyckaerts C, Yokoo H, Nakazato Y, Jaros E, Perry RH, Arnold SE, Lee VM, Trojanowski JQ. Acta neuropathologica. 2004 108:213-23. [PubMed:15170578] [PMC:PMC3516855]

Demonstration of natural autoantibodies against the neurofilament protein alpha-internexin in sera of patients with endocrine autoimmunity and healthy individuals. Rajasalu T, Teesalu K, Janmey PA, Uibo R. Immunology letters. 2004 94:153-60. [PubMed:15234547]

Clinical and neuropathologic variation in neuronal intermediate filament inclusion disease. Cairns NJ, Grossman M, Arnold SE, Burn DJ, Jaros E, Perry RH, Duyckaerts C, Stankoff B, Pillon B, Skullerud K, Cruz-Sanchez FF, Bigio EH, Mackenzie IR, Gearing M, Juncos JL, Glass JD, Yokoo H, Nakazato Y, Mosaheb S, Thorpe JR, Uryu K, Lee VM, Trojanowski. Neurology. 2004 63:1376-84. [PubMed:15505152] [PMC:PMC3516854]

Extending the clinicopathological spectrum of neurofilament inclusion disease. Josephs KA, Uchikado H, McComb RD, Bashir R, Wszolek Z, Swanson J, Matsumoto J, Shaw G, Dickson DW. Acta neuropathologica. 2005 109:427-32. [PubMed:15754170]

p55 protein is a member of PSD scaffold proteins in the rat brain and interacts with various PSD proteins. Jing-Ping Z, Tian QB, Sakagami H, Kondo H, Endo S, Suzuki T. Brain research. Molecular brain research. 2005 135:204-16. [PubMed:15857683]

Overexpression of neuronal intermediate filament protein alpha-internexin in PC12 cells. Chien CL, Liu TC, Ho CL, Lu KS. Journal of neuroscience research. 2005 80:693-706. [PubMed:15880430]

Screening for neurofilament inclusion disease using alpha-internexin immunohistochemistry. Uchikado H, Shaw G, Wang DS, Dickson DW. Neurology. 2005 64:1658-9. [PubMed:15883343]

Expression of intermediate filament proteins and neuronal markers in the human fetal gut. Rauch U, Klotz M, Maas-Omlor S, Wink E, Hnsgen A, Hagl C, Holland-Cunz S, Schfer KH. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 2006 54:39-46. [PubMed:16087706]

The expression of alpha-internexin and peripherin in the developing mouse pineal gland. Ko TL, Chien CL, Lu KS. Journal of biomedical science. 2005 12:777-89. [PubMed:16132113]

Neural expression of alpha-internexin promoter in vitro and in vivo. Wang P, Wang SM, Hsieh CJ, Chien CL. Journal of cellular biochemistry. 2006 97:275-87. [PubMed:16173078]

Angiotensin II increases GABAB receptor expression in nucleus tractus solitarii of rats. Yao F, Sumners C, O'Rourke ST, Sun C. American journal of physiology. Heart and circulatory physiology. 2008 294:H2712-20. [PubMed:18424635]

Neuron-glia interactions underlie ALS-like axonal cytoskeletal pathology. King AE, Dickson TC, Blizzard CA, Woodhouse A, Foster SS, Chung RS, Vickers JC. Neurobiology of aging. 2011 32:459-69. (ICC, IHC; Mouse) [PubMed:19427060]

Focal damage to the adult rat neocortex induces wound healing accompanied by axonal sprouting and dendritic structural plasticity. Blizzard CA, Chuckowree JA, King AE, Hosie KA, McCormack GH, Chapman JA, Vickers JC, Dickson TC. Cerebral cortex (New York, N.Y. : 1991). 2011 21:281-91. (IHC; Rat) [PubMed:20511339]

Alpha-internexin expression predicts outcome in anaplastic oligodendroglial tumors and may positively impact the efficacy of chemotherapy: European organization for research and treatment of cancer trial 26951. Mokhtari K, Ducray F, Kros JM, Gorlia T, Idbaih A, Taphoorn M, Wesseling P, Hoang-Xuan K, Van den Bent M, Sanson M. Cancer. 2011 117:3014-26. (IHC-P; Human) [PubMed:21246521]

Fronto-temporal lobar degeneration: neuropathology in 60 cases. Seilhean D, Le Ber I, Sarazin M, Lacomblez L, Millecamps S, Salachas F, Pradat PF, Le Forestier N, LeGuern E, Dubois B, Meininger V, Brice A, Hauw JJ, Duyckaerts C. Journal of neural transmission (Vienna, Austria : 1996). 2011 118:753-64. (IHC; Human) [PubMed:21541771]

Immunohistochemical detection of IDH1 mutation, p53, and internexin as prognostic factors of glial tumors. Takano S, Kato Y, Yamamoto T, Kaneko MK, Ishikawa E, Tsujimoto Y, Matsuda M, Nakai K, Yanagiya R, Morita S, Tsuboi K, Matsumura A. Journal of neuro-oncology. 2012 108:361-73. (IHC; Human) [PubMed:22396072]

Degeneration of axons in spinal white matter in G93A mSOD1 mouse characterized by NFL and alpha-internexin immunoreactivity. King AE, Blizzard CA, Southam KA, Vickers JC, Dickson TC. Brain research. 2012 1465:90-100. (ICC, IHC; Mouse) [PubMed:22609817]

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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