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IL6R / IL6 Receptor

interleukin 6 receptor

IL6R / IL6 Receptor is a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.

Gene Name: interleukin 6 receptor
Family/Subfamily: Interleukin
Synonyms: IL6R, CD126, gp80, IL-6R subunit alpha, IL-6R-alpha, IL-6RA, IL6Q, IL-6 receptor subunit alpha, IL-6R 1, IL-6R-1, Interleukin 6 receptor, Membrane glycoprotein 80, CD126 antigen, IL6RA, IL6RQ
Target Sequences: NM_000565 NP_000556.1 P08887

Publications (2)

1
Interleukin 6 regulates psoriasiform inflammation-associated thrombosis. Wang Y, Golden JB, Fritz Y, Zhang X, Diaconu D, Camhi MI, Gao H, Dawes SM, Xing X, Ganesh SK, Gudjonsson JE, Simon DI, McCormick TS, Ward NL. JCI insight. 2016 1:e89384. (IHC-P; Human) [Full Text Article] [PubMed:27942589] [PMC:PMC5135273] Related Antibodies: LS-B6362.
2
Rapid monocyte infiltration following retinal detachment is dependent on non-canonical IL6 signaling through gp130. Wang X, Miller EB, Goswami M, Zhang P, Ronning KE, Karlen SJ, Zawadzki RJ, Pugh EN Jr, Burns ME. Journal of neuroinflammation. 2017 14:121. (WB; Mouse) [Full Text Article] [PubMed:28645275] [PMC:PMC5481880] Related Antibodies: LS-C70920.

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Antibodies (132)
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IL6R / IL6 Receptor (192)
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IL6R / IL6 Receptor Antibody - Anti-IL6R antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.
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IL6R / IL6 Receptor Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$460
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IL6R / IL6 Receptor Rat anti-Mouse Monoclonal (Extracellular Domain) Antibody
Mouse
ELISA, WB
Unconjugated
100 µg/$907
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IL6R / IL6 Receptor Mouse anti-Human Monoclonal (B-R6) Antibody
Human
ELISA, Flo, IF, IHC, IHC-Fr, IP
Unconjugated
0.1 mg/$385
IL6R / IL6 Receptor Antibody - IHC of paraffin-embedded Human lymph node tissue using anti-IL6R mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).
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IL6R / IL6 Receptor Mouse anti-Human Monoclonal (OTI2F4) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$450
IL6R / IL6 Receptor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
12.5 - 800 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$768
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CHO Cells
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
54-56 kDa (SDS-PAGE)
50 µg/$615; 10 µg/$304
IL6R / IL6 Receptor ELISA Kit
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Sandwich
96-Well Microplate
Mouse
6.144 - 1500 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$700
IL6R / IL6 Receptor Antibody - Western blot of recombinant IL6R / IL6 Receptor.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IL6R / IL6 Receptor Rabbit anti-Rat Polyclonal (aa19-108) Antibody
Rat
WB
Unconjugated
100 µl/$312; 200 µl/$355; 500 µl/$500; 1 ml/$573; 2 ml/$780; 5 ml/$1,268
IL6R / IL6 Receptor Antibody - Western blot of recombinant IL6R / IL6 Receptor.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IL6R / IL6 Receptor Rabbit anti-Rat Polyclonal (aa19-108) (Biotin) Antibody
Rat
WB
Biotin Conjugated
100 µl/$322; 200 µl/$370; 500 µl/$529; 1 ml/$614; 2 ml/$846; 5 ml/$1,395
IL6R / IL6 Receptor Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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IL6R / IL6 Receptor Rabbit anti-Human Polyclonal (aa216-356) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
IL6R / IL6 Receptor ELISA Kit
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Sandwich
96-Well Microplate
Human
4.1 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$588
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IL6R / IL6 Receptor Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, ICC
Unconjugated
100 µg/$848
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IL6R / IL6 Receptor Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, IHC, IHC-Fr, IP
Unconjugated
100 µg/$801
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IL6R / IL6 Receptor Mouse anti-Human Monoclonal (B-R6) Antibody
Human
ELISA, Flo, Func, IHC, IHC-Fr, IP
Unconjugated
100 µg/$597
IL6R / IL6 Receptor Antibody - Western Blot; Sample: Recombinant protein.
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IL6R / IL6 Receptor Rabbit anti-Rat Polyclonal (aa214-348) Antibody
Rat
WB
Unconjugated
100 µl/$312; 200 µl/$355; 500 µl/$500; 1 ml/$573; 2 ml/$780; 5 ml/$1,268
IL6R / IL6 Receptor Antibody - 1:100 staining human urothelial carcinoma tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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IL6R / IL6 Receptor Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
IL6R / IL6 Receptor Antibody - Western Blot analysis of extracts from AD293, 4T1 cells using IL6R Antibody.
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IL6R / IL6 Receptor Rabbit anti-Human Polyclonal (aa221-270) Antibody
Human
ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
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IL6R / IL6 Receptor Mouse anti-Human Monoclonal (17506) Antibody
Human
ELISA, Flo, Neut, WB
Unconjugated
100 µg/$962
IL6R / IL6 Receptor Protein - Purified recombinant protein IL6R was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
49.8 kDa
20 µg/$1,107
IL6R / IL6 Receptor ELISA Kit
Select
Sandwich
96-Well Microplate
Rat
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
IL6R / IL6 Receptor Protein - Measured by its ability to enhance the activity of IL6 on M1 mouse myeloid leukemia cells. The ED50 for this effect is typically 30-125 ng/mL in the presence of 100 ng/mL of recombinant human IL6.
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HEK 293 Cells
Human IgG Fc, C-terminus
SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human IL6R consists of 464 amino acids and predicts a molecular mass of 52.2 kDa.
100 µg/$480; 1 mg/$2,333
IL6R / IL6 Receptor ELISA Kit
Select
Sandwich
12 x 8-Well Microstrips
Human
16 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum
1 Plate/$618
Select
CHO Cells
Mouse IgG2 Fc
Biologically active
Less than 0.06 EU/µg protein (determined by LAL method).
50 µg/$442
Select
IL6R / IL6 Receptor Rat anti-Mouse Monoclonal (Extracellular Domain) Antibody
Mouse
Flo, ICC
Unconjugated
500 µg/$1,089
Select
IL6R / IL6 Receptor Rabbit anti-Human Polyclonal (aa23-371) Antibody
Human
ELISA, IP, WB
Unconjugated
100 µg/$341
Viewing 1-25 of 192 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).