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IL4

interleukin 4

IL4 is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Gene Name: interleukin 4
Family/Subfamily: Hormone , not assigned-Hormone
Synonyms: IL4, B cell growth factor 1, B-cell stimulatory factor 1, B_cell stimulatory factor 1, BCGF1, BSF-1, Binetrakin, BCGF-1, Interleukin 4, Interleukin-4, Pitrakinra, BSF1, IL-4
Target Sequences: NM_000589 NP_000580.1 P05112

Publications (3)

1
Phosphoantigen-activated V gamma 2V delta 2 T cells antagonize IL-2-induced CD4+CD25+Foxp3+ T regulatory cells in mycobacterial infection. Gong G, Shao L, Wang Y, Chen CY, Huang D, Yao S, Zhan X, Sicard H, Wang R, Chen ZW. Blood. 2009 113:837-45. [PubMed:18981295] [PMC:PMC2630269] Related Antibodies: LS-C41019.
2
Modulation of Binge-like Ethanol Consumption by IL-10 Signaling in the Basolateral Amygdala. S Alex Marshall, Kyle H McKnight, Allyson K Blose, Donald T Lysle, Todd E Thiele. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2017 June;12:249-259. [Full Text Article] [PubMed:27640210] [PMC:PMC5357210] Related Antibodies: LS-C745952.
3
Delivery of Interleukin-4-Encoding Lentivirus Using Multiple-Channel Bridges Enhances Nerve Regeneration. S Ahmed Ali, John E Hanks, Aaron W Stebbins, Osama Alkhalili, Samantha T Cohen, Jessica Y Chen, Dominique R Smith, Courtney M Dumont, Lonnie D Shea, Norman D Hogikyan, Eva L Feldman, Michael J Brenner. The Laryngoscope. 2020 December;130:2802-2810. [Full Text Article] [PubMed:32220076] [PMC:PMC7893531] Related Antibodies: LS-C408858.

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IL4 Antibody - Anti-IL-4 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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IL4 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$485
IL4 Antibody - IL4 Antibody IHC of formalin-fixed and paraffin-embedded tonsil followed by peroxidase-conjugated secondary antibody and DAB staining.
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IL4 Rabbit anti-Human Polyclonal (aa122-150) Antibody
Mouse, Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
Select
IL4 Rat anti-Human Monoclonal (PerCP) (MP4-25D2) Antibody
Human
ELISA, Flo, IHC
PerCP Conjugated
25 µg/$236; 100 µg/$251
Select
IL4 Mouse anti-Human Monoclonal (860A 4B3) Antibody
Human
ELISA, SwELISA
Unconjugated
500 µg/$780
IL4 Antibody
Select
IL4 Mouse anti-Human Monoclonal (8D4-8) Antibody
Human, Monkey
ELISA, Flo, IHC, IP
Unconjugated
50 µg/$264
IL4 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Yeast
6His, N-terminus
1 mg/$1,973; 100 µg/$679; 20 µg/$429
IL4 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Canine
6.25 - 400 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$768
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CHO Cells
Human IgG1 Fc, C-terminus
Less than 0.06 EU/µg protein (determined by LAL method).
43 kDa (predicted)
50 µg/$428; 10 µg/$337
IL4 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Chicken
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$818
IL4 Antibody - Immunohistochemistry of paraffin-embedded human liver injury tissue.
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IL4 Rabbit anti-Human Polyclonal Antibody
Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
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CHO Cells
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
15 kDa (SDS-PAGE)
50 µg/$342; 10 µg/$286; 1 mg/$1,612
IL4 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$795
IL4 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Guinea pig
3.13 - 200 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$854
IL4 Antibody - 1:100 staining human uterus tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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IL4 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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IL4 Rat anti-Mouse Monoclonal (PE) Antibody
Mouse
Flo
PE Conjugated
500 µl/$1,009
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IL4 Mouse anti-Bovine Monoclonal (PE) Antibody
Goat, Dog, Sheep, Bovine, Pig, Mustelid
Flo
PE Conjugated
100 Tests/$984
IL4 Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
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IL4 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC-P
Unconjugated
50 µg/$460
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IL4 Rat anti-Mouse Monoclonal Antibody
Mouse
ELISA, IHC, IP, WB
Unconjugated
500 µg/$763; 1 mg/$957
IL4 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Dog
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Biological Fluids, Plasma, Serum, Tissue Homogenates
1 Plate/$783
IL4 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$669
IL4 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
13.4 kDa
50 µg/$487; 10 µg/$303; 1 mg/$2,837; 500 µg/$1,987
IL4 Protein
Select
E. coli
None
Biologically active
14.9 kDa
5 µg/$267; 20 µg/$351; 100 µg/$874; 250 µg/$1,382; 1 mg/$2,839; 500 µg/$1,917
Select
IL4 Goat anti-Rabbit Polyclonal Antibody
Rabbit
ELISA, WB
Unconjugated
0.1 mg/$596
Select
IL4 Mouse anti-Bovine Monoclonal (CC313) Antibody
Bovine
ELISA
Unconjugated
0.5 mg/$571
Select
IL4 Mouse anti-Pig Monoclonal Antibody
Pig
ELISA
Unconjugated
500 µg/$631
Viewing 1-25 of 420 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).