Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone CD123-D3] (IgG1,k) to Human IL3RA / CD123
IHC, IHC - Paraffin, IHC - Frozen
Mouse Monoclonal [clone 6H6] (IgG1,k) to Human IL3RA / CD123
PE, Cy7 Conjugated
Human IL3RA / CD123
Human (tested or 100% immunogen sequence identity)
IgG1,k Monoclonal [6H6]
Specificity and Use
IL3RA / CD123 antibody was raised against human IL3RA
This 6H6 antibody has been pre-titrated and tested by flow cytometric analysis of human peripheral blood leukocytes. This can be used at 5 ul (0.25 ug)/per test. A test is defined as the amount (ug)/test of antibody that will stain a cell sample in a final volume of 100 ul. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
PBS, pH 7.2, <=0.09% sodium azide, protein stabilizer
IL3RA / CD123 is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3.
Staining of normal human peripheral blood cells with PE-Cy7 Mouse IgG1, K isotype control (open histogram) or PE-Cy7 anti-human CD123 (6H6) (colored histogram). Cells in the lymphocyte gate were used for analysis. This image was taken for the unconjugated form of this product. Other forms have not been tested.