Target
Mouse IL2RB / CD122
Synonyms
IL2RB | CD122 | CD122 antigen | IL-2 receptor subunit beta | IL15RB | Interleukin 15 receptor, beta | p70-75 | IL-2R subunit beta | IL-2RB | Interleukin 2 receptor, beta
Reactivity
Mouse
(tested or 100% immunogen sequence identity)
Modifications
Low Endotoxin.
Also available
Unmodified.
Immunogen
Cells from murine IL-2RB + transformant TART-mBeta.
Specificity
Recognizes the murine CD122 cell surface glycoprotein, a 75-85kD molecule also known as interleukin-2 receptor (IL-2R) beta chain. In mouse, CD122 is primarily expressed on natural killer (NK) cells and at lower levels on lymphocyte subsets, monocytes and macrophages. CD122 can associate with the IL-2R alpha chain (CD25) and CD132 to form a functional high affinity receptor complex that binds IL-2. CD132/CD122 heterodimers can also be formed which bind IL-2 with intermediate affinity. IL-2 binding to the IL-2R is important in the generation and differentiation of T lymphocytes and NK cells. Clone TM-beta 1 is reported to block IL-2 high affinity binding to the IL-2R beta receptor. XXX recommend the use of For this purpose.