Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 4C9] (IgG2b) to Human IL2RA / CD25
IHC, IHC - Paraffin, IHC - Frozen
Rat Monoclonal [clone PC61.5.3] (IgG1) to Mouse IL2RA / CD25
Mouse IL2RA / CD25
Mouse (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [PC61.5.3]
Flow Cytometry (1 µg/10E6 cells)
Specificity and Use
IL2RA / CD25 antibody was raised against b6.1 CTL cell line.
Cedarlane's anti-mouse CD25 (IL-2R) monoclonal antibody reacts with the low affinity alpha chain of the interleukin-2 receptor antigen present on activated T and B cells in mice. Inhibits IL-2 binding and IL-2 dependent proliferation. This antibody is suitable for use in flow cytometry
The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis.