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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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IL23A / IL‑23 p19 Antibody (clone HLT2736) IHC‑plus™ LS‑B3708
Note: This antibody replaces LS-C40934
IL-23 p19 antibody LS-B3708 is an unconjugated mouse monoclonal antibody to human IL-23 p19 (IL23A). Validated for IHC and WB. Tested on 20 paraffin-embedded human tissues. Cited in 3 publications.
Catalog
Size
Price
LS-B3708-50
50 µg (0.5 mg/ml)
Unavailable

Popular IL23A / IL-23 p19 Products

Anti-IL-23 p19 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B573 concentration 5 ug/ml.
Species: Human, Mouse
Applications: IHC, IHC - Paraffin, Western blot
Anti-IL-23 p19 antibody IHC staining of mouse kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1366 concentration 5 ug/ml.
Species: Human
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Antibody
Species: Human
Applications: Western blot, ELISA, Sandwich ELISA
Antibody
Species: Human, Mouse
Applications: IHC, Western blot

Product Description

IL-23 p19 antibody LS-B3708 is an unconjugated mouse monoclonal antibody to human IL-23 p19 (IL23A). Validated for IHC and WB. Tested on 20 paraffin-embedded human tissues. Cited in 3 publications.
About IL23A / IL-23 p19
Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. Q9NPF7 NM_016584 NP_057668.1

IL23A Antibody, IL-23 subunit alpha Antibody, IL-23A Antibody, Interleukin 23 p19 subunit Antibody, Interleukin-23 subunit alpha Antibody, IL23P19 Antibody, Interleukin-23 subunit p19 Antibody, p19 Antibody, SGRF Antibody, IL-23 Antibody, IL-23 p19 Antibody, IL-23-A Antibody, IL-23p19 Antibody


Specifications

Target
Human IL23A / IL-23 p19
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG1 Monoclonal [HLT2736]
Conjugations
Unconjugated
Purification
Affinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (10 µg/ml)
  • Western blot
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Recombinant human IL23A / IL-23.
Specificity
Human recombinant p40 and p19 with elastin linker
Usage
Immunohistochemistry: LS-B3708 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B3708 was determined to be 10 ug/ml.
Presentation
Phosphate-buffered solution, pH 7.2, 0.09% sodium azide. Sourced in TCS.
Storage
4°C. Store undiluted.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

Publications (3)

1
The involvement of IL-23 and the Th17 pathway in periodontitis. Ohyama H, Kato-Kogoe N, Kuhara A, Nishimura F, Nakasho K, Yamanegi K, Yamada N, Hata M, Yamane J, Terada N. Journal of dental research. 2009 88:633-8. [PubMed:19605880]
2
Systemic and local interleukin-17 and linked cytokines associated with Sjgren's syndrome immunopathogenesis. Katsifis GE, Rekka S, Moutsopoulos NM, Pillemer S, Wahl SM. The American journal of pathology. 2009 175:1167-77. [PubMed:19700754] [PMC:PMC2731135]
3
Proteasome inhibitors prevent caspase-1-mediated disease in rodents challenged with anthrax lethal toxin. Muehlbauer SM, Lima H, Goldman DL, Jacobson LS, Rivera J, Goldberg MF, Palladino MA, Casadevall A, Brojatsch J. The American journal of pathology. 2010 177:735-43. [PubMed:20595632] [PMC:PMC2913046]

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Images


Immunohistochemistry

Anti-IL-23 p19 antibody IHC of human lung, vasculature. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3708 concentration 10 ug/ml.
Anti-IL-23 p19 antibody IHC of human lung, vasculature. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3708 concentration 10 ug/ml.

Immunohistochemistry

Anti-IL-23 p19 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3708 concentration 10 ug/ml.
Anti-IL-23 p19 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3708 concentration 10 ug/ml.

Western blot

Linker-free, recombinant human IL-23 was resolved by electrophoresis, transferred to nitrocellulose and probed with the anti-IL23 p19 specific antibody HLT2736 antibody. Proteins were visualized using a goat anti-mouse secondary conjugated to HRP and a ch.
Linker-free, recombinant human IL-23 was resolved by electrophoresis, transferred to nitrocellulose and probed with the anti-IL23 p19 specific antibody HLT2736 antibody. Proteins were visualized using a goat anti-mouse secondary conjugated to HRP and a ch.

Immunohistochemistry

Anti-IL-23 p19 antibody IHC of human lung, vasculature. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3708 concentration 10 ug/ml.
Anti-IL-23 p19 antibody IHC of human lung, vasculature. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3708 concentration 10 ug/ml.

Immunohistochemistry

Anti-IL-23 p19 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3708 concentration 10 ug/ml.
Anti-IL-23 p19 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3708 concentration 10 ug/ml.

Western blot

Linker-free, recombinant human IL-23 was resolved by electrophoresis, transferred to nitrocellulose and probed with the anti-IL23 p19 specific antibody HLT2736 antibody. Proteins were visualized using a goat anti-mouse secondary conjugated to HRP and a ch.
Linker-free, recombinant human IL-23 was resolved by electrophoresis, transferred to nitrocellulose and probed with the anti-IL23 p19 specific antibody HLT2736 antibody. Proteins were visualized using a goat anti-mouse secondary conjugated to HRP and a ch.

Immunohistochemistry

Anti-IL-23 p19 antibody IHC of human lung, vasculature. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3708 concentration 10 ug/ml.
Anti-IL-23 p19 antibody IHC of human lung, vasculature. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3708 concentration 10 ug/ml.

Immunohistochemistry

Anti-IL-23 p19 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3708 concentration 10 ug/ml.
Anti-IL-23 p19 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3708 concentration 10 ug/ml.

Western blot

Linker-free, recombinant human IL-23 was resolved by electrophoresis, transferred to nitrocellulose and probed with the anti-IL23 p19 specific antibody HLT2736 antibody. Proteins were visualized using a goat anti-mouse secondary conjugated to HRP and a ch.
Linker-free, recombinant human IL-23 was resolved by electrophoresis, transferred to nitrocellulose and probed with the anti-IL23 p19 specific antibody HLT2736 antibody. Proteins were visualized using a goat anti-mouse secondary conjugated to HRP and a ch.

Immunohistochemistry

Anti-IL-23 p19 antibody IHC of human lung, vasculature. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3708 concentration 10 ug/ml.
Anti-IL-23 p19 antibody IHC of human lung, vasculature. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3708 concentration 10 ug/ml.

Immunohistochemistry

Anti-IL-23 p19 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3708 concentration 10 ug/ml.
Anti-IL-23 p19 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3708 concentration 10 ug/ml.

Western blot

Linker-free, recombinant human IL-23 was resolved by electrophoresis, transferred to nitrocellulose and probed with the anti-IL23 p19 specific antibody HLT2736 antibody. Proteins were visualized using a goat anti-mouse secondary conjugated to HRP and a ch.
Linker-free, recombinant human IL-23 was resolved by electrophoresis, transferred to nitrocellulose and probed with the anti-IL23 p19 specific antibody HLT2736 antibody. Proteins were visualized using a goat anti-mouse secondary conjugated to HRP and a ch.


Requested From: 
Date Requested: 6/23/2018

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