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IL21

interleukin 21

Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG1 and IgG3 in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.

Gene Name: interleukin 21
Family/Subfamily: Interleukin
Synonyms: IL21, Interleukin 21, Interleukin-21, Interleukin-21 isoform, Za11, IL-21
Target Sequences: NM_021803 NP_068575.1 Q9HBE4

Publications (3)

1
Selective localization of T helper subsets in labial salivary glands from primary Sjögren's syndrome patients. Maehara T, Moriyama M, Hayashida JN, Tanaka A, Shinozaki S, Kubo Y, Matsumura K, Nakamura S. Clinical and experimental immunology. 2012 169:89-99. (IHC; Human) [Full Text Article] [PubMed:22774983] [PMC:PMC3406368] Related Antibodies: LS-B1364.
2
CD4 T cell-intrinsic role for the T helper 17 signature cytokine IL-17: Effector resistance to immune suppression. Michael P Crawford, Sushmita Sinha, Pranav S Renavikar, Nicholas Borcherding, Nitin J Karandikar. Proceedings of the National Academy of Sciences of the United States of America. 2020 August;117:19408-19414. [Full Text Article] [PubMed:32719138] [PMC:PMC7430972] Related Antibodies: LS-C104584.
3
Interleukin-21 contributes to germinal centre formation and immunoglobulin G4 production in IgG4-related dacryoadenitis and sialoadenitis, so-called Mikulicz's disease. Maehara T, Moriyama M, Nakashima H, Miyake K, Hayashida JN, Tanaka A, Shinozaki S, Kubo Y, Nakamura S. Annals of the rheumatic diseases. 2012 Dec;71:2011-19. [Full Text Article] [PubMed:22753386] Related Antibodies: LS-B1364.

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Antibodies (90)
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IL21 Antibody - Anti-IL21 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
IL21 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, ICC, IHC, IHC-P, WB
Unconjugated
0.05 mg/$545
IL21 Antibody - Anti-Human IL-21 Western Blot Reduced
Select
IL21 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$356; 100 µg/$396
Select
IL21 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
25 µg/$356; 50 µg/$396
IL21 Antibody - Anti-Murine IL-21 Western Blot Reduced
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IL21 Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, WB
Unconjugated
50 µg/$356; 100 µg/$396
IL21 Antibody - Sandwich ELISA of IL-21 antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IL21 Rabbit anti-Mouse Polyclonal (Biotin) Antibody
Mouse
ELISA, WB
Biotin Conjugated
25 µg/$356; 50 µg/$396
Select
IL21 Rabbit anti-Human Polyclonal (aa118-146) Antibody
Human
ELISA, ICC
Unconjugated
100 µg/$556
IL21 ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Human
1.37 - 1000 pg/ml
Chemiluminescent
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$968
IL21 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$856
IL21 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Dog
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Select
IL21 Goat anti-Human Polyclonal (aa40-68) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$500
Select
IL21 Mouse anti-Human Monoclonal (SB134b) Antibody
Human
ELISA
Unconjugated
0.5 mg/$383
IL21 Antibody - Western blot of IL21 antibody.
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IL21 Rabbit anti-Human Polyclonal (aa23-155) (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$331; 200 µl/$383; 500 µl/$556; 1 ml/$665; 2 ml/$901; 5 ml/$1,511
IL21 Antibody - Western blot of IL21 antibody.
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IL21 Rabbit anti-Human Polyclonal (aa23-155) (APC) Antibody
Human
WB
APC Conjugated
100 µl/$396; 200 µl/$476; 500 µl/$815; 1 ml/$969; 2 ml/$1,240; 5 ml/$2,325
Select
E. coli
His
Less than 1.0 EU/µg protein (determined by LAL method).
50 µg/$587; 10 µg/$337
Select
IL21 Goat anti-Human Polyclonal (aa33-61) Antibody
Human
ELISA, ICC
Unconjugated
100 µg/$556
IL21 Antibody - Anti-bovine IL-21 Antibody - Western Blot. Western blot of anti-bovine IL-21 antibody shows detection of recombinant bovine IL-21 at 15.1kD (arrow) raised in yeast. Protein was purified and resolved by SDS-PAGE, transferred to PVDF membrane. Membrane was blocked with 3% BSA (BSA-30, diluted 1:10), and probed with Anti-bovine IL-21. After washing, membrane was probed with Dylight 649 Conjugated Anti-Rabbit IgG (H&L) (Donkey) Antibody (.
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IL21 Rabbit anti-Bovine Polyclonal (aa24-152) (Lyophilized) Antibody
Bovine, Pig, Horse
ELISA, WB
Unconjugated, Lyophilized
100 µg/$567
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IL21 Rabbit anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
20 µl/$271; 100 µl/$412
Select
IL21 Rabbit anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
20 µl/$256; 100 µl/$412
IL21 Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
IL21 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
Select
IL21 Mouse anti-Human Monoclonal (Biotin) (SB134f) Antibody
Human
ELISA
Biotin Conjugated
0.5 mg/$395
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IL21 Rabbit anti-Human Polyclonal (HRP) Antibody
Mouse, Human
WB
HRP Conjugated
100 µl/$937
IL21 Antibody - Anti-IL21 rabbit polyclonal antibody at 1:500 dilution. Lane A: HL-60 Whole Cell Lysate. Lane B: Rat spleen tissue lysate. Lane C: Rat brain tissue lysate. Lysates/proteins at 30 ug per lane. Secondary: Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size: 17 kDa. Observed band size: 16 kDa.
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IL21 Rabbit anti-Rat Polyclonal Antibody
Rat
WB
Unconjugated
100 µl/$412
IL21 Antibody - Immunohistochemistry of paraffin-embedded rat spleen tissue.
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IL21 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
IL21 ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Mouse
12.5 - 800 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
Select
E. coli
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
15.4 kDa (SDS-PAGE)
50 µg/$478; 10 µg/$296; 1 mg/$2,653
Viewing 1-25 of 167 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).